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Article
The relationship between root endophytic microbial of plant species and soil properties in different patches of alpine meadow
Plants do not live alone as single entities but are closely associated with an incredible diversity of bacteria, fungi and other organisms. To explore the advantages of endophytes in controlling ecosystem resp...
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Article
Open AccessDevelo** a medium combination to attain similar glycosylation profile to originator by DoE and cluster analysis method
Glycosylation is critical for monoclonal antibody production because of its impact on pharmacokinetics and pharmacodynamics. Modulation of glycan profile is frequently needed in biosimilar development. However...
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Article
The probability density function of interspike intervals in an FHN model with α-stable noise
In this paper, we expand the paradigmatic Fitzhugh–Nagumo (FHN) model by including α-stable noise and study the firing rate and coherence resonance via probability density function (PDF) of the interspike inte...
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Article
Design, Expression, Purification and Characterization of the Recombinant Immunotoxin 4D5 scFv-TRAIL
Immunotoxins are chimeric proteins that combine antibodies and toxins in targeted cancer therapy. Despite the promising application prospects, immunogenicity and nonspecific cytotoxicity of immunotoxins with t...
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Article
Open AccessGroEL/ES mediated the in vivo recovery of TRAIL inclusion bodies in Escherichia coli
Inclusion body (IB) formation generates substantial bio-waste in the pharmaceutical industry and remains a major challenge for heterologous protein expression. Although chaperones can be co-expressed to improv...
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Article
Open AccessHigher non-HDL-cholesterol to HDL-cholesterol ratio linked with increased nonalcoholic steatohepatitis
Non-HDL-cholesterol to HDL-cholesterol (non-HDL-c/HDL-c) ratio is a feasible predictor for coronary heart disease, metabolic syndrome, and insulin resistance. Patients with nonalcoholic steatohepatitis (NASH) ...
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Article
Open AccessBerberine increases adipose triglyceride lipase in 3T3-L1 adipocytes through the AMPK pathway
Obesity is closely related to the metabolism of triacylglycerol (TG) in adipocytes. Adipose triglyceride lipase (ATGL) and hormone-sensitive lipase (HSL) are rate-limiting enzymes that control the hydrolysis o...
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Article
Open AccessDistribution Characteristics of TOC, TN and TP in the Wetland Sediments of Longbao Lake in the San-Jiang Head Waters
The study deals with the distribution of nutrients in wetland sediments, which provide the basis for revealing the wetland eutrophication processes and mechanisms of internal pollution sources. The total organ...
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Article
Open AccessMetabolic engineering of Serratia marcescens MG1 for enhanced production of (3R)-acetoin
Optically pure acetoin (AC) is an important platform chemical which has been widely used to synthesize novel optically active α-hydroxyketone derivatives and liquid crystal composites.
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Article
Lévy noise induced stochastic resonance in an FHN model
This paper aims to investigate the stochastic resonance (SR) in an FitzHugh-Nagumo (FHN) model with an additive Lévy noise numerically. The non-Gaussian Lévy noise is a kind of general random noise which is di...
