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  1. Article

    Open Access

    Anti-drug Antibody Sample Testing and Reporting Harmonization

    A clear scientific and operational need exists for harmonized bioanalytical immunogenicity study reporting to facilitate communication of immunogenicity findings and expedient review by industry and health aut...

    Darshana Jani, Robin Marsden, Michele Gunsior, Laura Schild Hay… in The AAPS Journal (2022)

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  2. Article

    Correction to: Development and Utility of an ELISA Method for Sensitive and Specific Detection of IgE Antidrug Antibodies

    During the production process, the author order of Zhandong Don Zhong and Lynn L. Jiang were inadvertently placed. Lynn L. Jiang is the first author of this manuscript; Zhandong Don Zhong is the last author.

    Lynn L. Jiang, Puneet Khandelwal, Adam W. Clarke, Ray Bakhtiar… in The AAPS Journal (2020)

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  3. No Access

    Article

    Development and Utility of an ELISA Method for Sensitive and Specific Detection of IgE Antidrug Antibodies

    Biologics can potentially induce unwanted immune responses, leading to formation of antidrug antibodies (ADA) of various affinity, isotypes, and subclasses. Among them, antigen and drug-specific immunoglobulin...

    Zhandong Don Zhong, Lynn L. Jiang, Puneet Khandelwal, Adam W. Clarke… in The AAPS Journal (2020)

  4. Article

    Open Access

    Drug Target Interference in Immunogenicity Assays: Recommendations and Mitigation Strategies

    Sensitive and specific methodology is required for the detection and characterization of anti-drug antibodies (ADAs). High-quality ADA data enables the evaluation of potential impact of ADAs on the drug pharma...

    Zhandong Don Zhong, Adrienne Clements-Egan, Boris Gorovits… in The AAPS Journal (2017)

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  5. No Access

    Article

    Ligand Binding Assays in the 21st Century Laboratory: Platforms

    Franklin P. Spriggs, Zhandong Don Zhong, Afshin Safavi, Darshana Jani… in The AAPS Journal (2012)