7 Result(s)
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Zeynep Kalender-Atak
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Article
Robust gene expression programs underlie recurrent cell states and phenotype switching in melanoma
Melanoma cells can switch between a melanocytic and a mesenchymal-like state. Scattered evidence indicates that additional intermediate state(s) may exist. Here, to search for such states and decipher their un...
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Article
Open AccessYin Yang 1 sustains biosynthetic demands during brain development in a stage-specific manner
The transcription factor Yin Yang 1 (YY1) plays an important role in human disease. It is often overexpressed in cancers and mutations can lead to a congenital haploinsufficiency syndrome characterized by cran...
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Article
SCENIC: single-cell regulatory network inference and clustering
SCENIC enables simultaneous regulatory network inference and robust cell clustering from single-cell RNA-seq data.
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Article
Open AccessIdentification of cis-regulatory mutations generating de novo edges in personalized cancer gene regulatory networks
The identification of functional non-coding mutations is a key challenge in the field of genomics. Here we introduce μ-cisTarget to filter, annotate and prioritize cis-regulatory mutations based on their putative...
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Article
Open AccessDecoding the regulatory landscape of melanoma reveals TEADS as regulators of the invasive cell state
Transcriptional reprogramming of proliferative melanoma cells into a phenotypically distinct invasive cell subpopulation is a critical event at the origin of metastatic spreading. Here we generate transcriptom...
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Article
Exome sequencing identifies mutation in CNOT3 and ribosomal genes RPL5 and RPL10 in T-cell acute lymphoblastic leukemia
Stein Aerts, Jan Cools and colleagues report exome sequencing of T-cell acute lymphoblastic leukemia. They identify recurrent somatic mutations in CNOT3 and ribosome genes RPL5 and RPL10.
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Protocol
Using cisTargetX to Predict Transcriptional Targets and Networks in Drosophila
Gene expression regulation is a fundamental biological process leading to complete organism development by controlling processes like cell type specification and differentiation. The accuracy of this process i...
