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    Somatic and germline mutations in the tumor suppressor gene PARK2 impair PINK1/Parkin-mediated mitophagy in lung cancer cells

    PARK2, which encodes Parkin, is a disease-causing gene for both neurodegenerative disorders and cancer. Parkin can function as a neuroprotector that plays a crucial role in the regulation of mitophagy, and germli...

    Zeng-li Zhang, Na-na Wang, Qi-lian Ma, Yang Chen, Li Yao in Acta Pharmacologica Sinica (2020)

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    Evaluation of the association between urinary cadmium levels below threshold limits and the risk of diabetes mellitus: a dose-response meta-analysis

    As cadmium levels are increasing in the environment, the adverse effects of cadmium exposure specifically associated with chronic diseases are receiving increasing attention. Several population–based studies h...

    Fei-Fei Guo, Zhi-Yong Hu, Bing-Yan Li in Environmental Science and Pollution Resear… (2019)

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    Circulating 25-hydroxyvitamin D and risk of lung cancer: a dose–response meta-analysis

    Mounting experimental evidence supports a protective effect of high 25-hydroxyvitamin D (25[OH]D), a good indicator of vitamin D status, on risk of various cancers including lung cancer. However, prospective o...

    Guo-Chong Chen, Zeng-Li Zhang, Zhongxiao Wan, Ling Wang in Cancer Causes & Control (2015)