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Article
PDLIM3 supports hedgehog signaling in medulloblastoma by facilitating cilia formation
Elevated levels of PDLIM3 expression are frequently detected in sonic hedgehog (SHH) group of medulloblastoma (MB). However, the possible role of PDLIM3 in MB tumorigenesis is still unknown. Here, we found tha...
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Article
Statins repress hedgehog signaling in medulloblastoma with no bone toxicities
The Hedgehog (Hh) pathway plays an indispensable role in bone development and genetic activation of the pathway results in medulloblastoma (MB), the most common malignant brain tumor in children. Inhibitors of...
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Article
Lipase-Catalyzed Highly Efficient 1,6-Conjugated Addition for Synthesis of Triarylmethanes
Lipase from porcine pancreas (PPL) is first reported to catalyze direct 1,6-conjugated addition for synthesis of triarylmethanes using p-quinonemethides (p-QMs) and 2-naphthols. The catalytic activity of PPL was ...
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Article
Open AccessCorrection to: c-MYC overexpression induces choroid plexus papillomas through a T-cell mediated inflammatory mechanism
In the original version of this article [1], there was 1 error in the affiliation of the European Institute of Oncology (affiliation 3). In this correction article the updated affiliation is shown for clarific...
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Article
Open Accessc-MYC overexpression induces choroid plexus papillomas through a T-cell mediated inflammatory mechanism
Choroid plexus tumours (CPTs) account for 2–5% of brain tumours in children. They can spread along the neuraxis and can recur after treatment. Little is known about the molecular mechanisms underlying their fo...
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Article
Biocatalytic One-Pot Three-Component Synthesis of Indoloquinolizines with High Diastereoselectivity
A facile and green method catalyzed by α-amylase has been developed for the synthesis of highly substituted indoloquinolizines using tryptamines, β-ketoesters and α,β-unsaturated aldehydes. The reaction afford...
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Article
A population of Nestin-expressing progenitors in the cerebellum exhibits increased tumorigenicity
In this study, the authors show that a subset of cerebellar granule neurons originate not from the granule neuron precursors (GNPs) but from a population of Nestin-expressing progenitors (NEPs) in the deep ext...
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Chapter and Conference Paper
Dynamic Analysis and Simulation of Arresting Wires
As the research object to arresting wires, it is first analysed that the landing(on or off center) model of airplane and the dynamics model of arresting wires under impact loading. Then, the motion equation of...
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Article
Subtypes of medulloblastoma have distinct developmental origins
Medulloblastomas, a common type of malignant childhood brain tumour, are thought in the main to arise from the cerebellum, many of them involving aberrant signalling of a signalling pathway involving Sonic Hed...
