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  1. Article

    Open Access

    Development of a machine learning-based radiomics signature for estimating breast cancer TME phenotypes and predicting anti-PD-1/PD-L1 immunotherapy response

    Since breast cancer patients respond diversely to immunotherapy, there is an urgent need to explore novel biomarkers to precisely predict clinical responses and enhance therapeutic efficacy. The purpose of our...

    **aorui Han, Yuan Guo, Huifen Ye, Zhihong Chen, Qingru Hu in Breast Cancer Research (2024)

  2. Article

    Open Access

    An artificial intelligence-based ecological index for prognostic evaluation of colorectal cancer

    In the tumor microenvironment (TME), the dynamic interaction between tumor cells and immune cells plays a critical role in predicting the prognosis of colorectal cancer. This study introduces a novel approach ...

    Qicong Chen, Ming Cai, **njuan Fan, Wenbin Liu, Gang Fang, Su Yao, Yao Xu in BMC Cancer (2023)

  3. Article

    Open Access

    Necrosis score as a prognostic factor in stage I–III colorectal cancer: a retrospective multicenter study

    Tumor necrosis results from failure to meet the requirement for rapid proliferation of tumor, related to unfavorable prognosis in colorectal cancer (CRC). However, previous studies used traditional microscopes...

    Huifen Ye, Yiting Wang, Su Yao, Zaiyi Liu, Changhong Liang, Yaxi Zhu in Discover Oncology (2023)

  4. Article

    Open Access

    An integrated deep learning model for the prediction of pathological complete response to neoadjuvant chemotherapy with serial ultrasonography in breast cancer patients: a multicentre, retrospective study

    The biological phenotype of tumours evolves during neoadjuvant chemotherapy (NAC). Accurate prediction of pathological complete response (pCR) to NAC in the early-stage or posttreatment can optimize treatment ...

    Lei Wu, Weitao Ye, Yu Liu, Dong Chen, Yuxiang Wang, Yanfen Cui in Breast Cancer Research (2022)

  5. Article

    Open Access

    Preoperative serum CA19-9 should be routinely measured in the colorectal patients with preoperative normal serum CEA: a multicenter retrospective cohort study

    Whether preoperative serum carbohydrate antigen 19–9 (CA19-9) is an independent prognostic factor and there are interactions of serum CA19-9 with carcinoembryonic antigen (CEA) on the risk of recurrence in col...

    Zhenhui Li, Haibin Zhu, **aolin Pang, Yun Mao, ** Yi, Chunxia Li in BMC Cancer (2022)

  6. Article

    Open Access

    The value of the tumour-stroma ratio for predicting neoadjuvant chemoradiotherapy response in locally advanced rectal cancer: a case control study

    The tumour-stroma ratio (TSR) is recognized as a practical prognostic factor in colorectal cancer. However, TSR assessment generally utilizes surgical specimens. This study aims to investigate whether the TSR ...

    Yanting Liang, Yaxi Zhu, Huan Lin, Shenyan Zhang, Suyun Li, Yanqi Huang in BMC Cancer (2021)