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Article
Analytical Model and Experimental Verification of the Interfacial Peeling Strength of Electrodes
The interfacial peeling strength of lithium-ion battery electrodes is a very important mechanical property that significantly affects the electrochemical performance of battery cells.
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Article
Review of Basalt-Fiber-Reinforced Cement-based Composites in China: Their Dynamic Mechanical Properties and Durability
The research performed in China on cement-based composites reinforced with randomly 3D distributed basalt fibers is analyzed and summarized, and six possible directions of further investigations into this fiel...
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Article
Oncolytic viruses as platform for multimodal cancer therapeutics: a promising land
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Article
Inhibitors of C5 complement enhance vaccinia virus oncolysis
Genetically engineered tumor-selective vaccinia virus (VV) has been demonstrated to be a highly effective oncolytic agent, but immune clearance may limit its therapeutic potential. As previously demonstrated, ...
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Article
Oncolytic poxvirus armed with Fas ligand leads to induction of cellular Fas receptor and selective viral replication in FasR-negative cancer
Tumor necrosis factor superfamily members, including Fas ligand and TRAIL, have been studied extensively for cancer therapy, including as components of gene therapy. We examined the use of FasL expression to a...
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Article
The combination of immunosuppression and carrier cells significantly enhances the efficacy of oncolytic poxvirus in the pre-immunized host
Pre-existing antipoxvirus immunity in cancer patients presents a severe barrier to poxvirus-mediated oncolytic virotherapy. We have explored strategies of immunosuppression (IS) and/or immune evasion for effic...
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Article
TRAIL gene-armed oncolytic poxvirus and oxaliplatin can work synergistically against colorectal cancer
We have explored a unique combination therapy for metastatic colorectal cancer. This strategy combines a potent and new oncolytic poxvirus expressing a membrane-bound tumor necrosis factor-related apoptosis-in...
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Article
JNK-deficiency enhanced oncolytic vaccinia virus replication and blocked activation of double-stranded RNA-dependent protein kinase
Vaccinia virus has recently been used as an expression vector for gene delivery and an oncolytic agent for cancer therapy. Although it has been established that interferon-induced double-stranded RNA (dsRNA)-a...
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Article
Oncolytic virotherapy for ovarian carcinomatosis using a replication-selective vaccinia virus armed with a yeast cytosine deaminase gene
In this study, we assessed the ability of a highly tumor-selective oncolytic vaccinia virus armed with a yeast cytosine deaminase gene to infect and lyse human and murine ovarian tumors both in vitro and in vivo....
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Article
A new recombinant vaccinia with targeted deletion of three viral genes: its safety and efficacy as an oncolytic virus
To enhance further the safety and efficacy of oncolytic vaccinia virus, we have developed a new virus with targeted deletions of three viral genes encoding thymidine kinase and antiapoptotic/host range protein...
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Article
Development of a tetracycline-inducible system for regulation of oncolytic vaccinia virus gene expression
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Chapter and Conference Paper
Eukaryotic Origins of DNA Replication
Initiation of DNA replication acts as a failsafe point in the cell proliferation cycle, because it is a commitment to cell division and, therefore, central to control of the eukaryotic cell cycle (Laskey et al...
