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Surgical Treatment of Pheochromocytoma and Retroperitoneal Paraganglioma
The location of PPGL varies greatly. Preoperative localization and diagnosis are particularly important. Not only the location of the tumor but also its size and its relationship with the surrounding anatomica...
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Article
Open AccessA novel signature for predicting prognosis and immune landscape in cutaneous melanoma based on anoikis-related long non-coding RNAs
Anoikis is a unique form of apoptosis associated with vascularization and distant metastasis in cancer. Eliminating anoikis resistance in tumor cells could be a promising target for improving the prognosis of ...
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Article
Open AccessComprehensive prediction of immune microenvironment and hot and cold tumor differentiation in cutaneous melanoma based on necroptosis-related lncRNA
As per research, causing cancer cells to necroptosis might be used as a therapy to combat cancer drug susceptibility. Long non-coding RNA (lncRNA) modulates the necroptosis process in Skin Cutaneous Melanoma (...
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Article
Open AccessExpanding the mutation and phenotype spectrum of MYH3-associated skeletal disorders
Pathogenic variants in MYH3 cause distal arthrogryposis type 2A and type 2B3 as well as contractures, pterygia and spondylocarpotarsal fusion syndromes types 1A and 1B. These disorders are ultra-rare and their na...
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Article
Open AccessMultiple inferior vena cava aneurysms mimic a retroperitoneal tumor: a case report
Inferior vena cava (IVC) aneurysms are extremely rare with variable clinical manifestations. Patients are usually asymptomatic or present with complications of thrombosis and rupture. To date, there have been ...
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Article
Open AccessChange in the cause of inpatient mortality after arthroplasty: a retrospective study
Although arthroplasty has been proved to be a safe and effective procedure, data regarding inpatient mortality rates associated with arthroplasty in China is unclear. We aimed to investigate the inpatient mort...
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Article
The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease
With the recent advance in genome-wide association studies (GWAS), disease-associated single nucleotide polymorphisms (SNPs) and copy number variants (CNVs) have been extensively reported. Accordingly, the iss...
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Molecular therapeutic strategies for FGFR3 gene-related skeletal dysplasia
The FGFR3 gene encodes fibroblast growth factor receptor 3 protein, a negative regulator of chondrogenesis. Gain-of-function mutations result in constitutively activated FGFR3, leading to aberrant signal transduc...
