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  1. Article

    Open Access

    Central emotions and hubs in a colexification network

    By focusing on colexification, we detected central emotions sharing semantic commonalities with many other emotions in terms of a semantic relationship of both similarity and associativity. In analysis, we cre...

    Mitsuki Fukuya, Tomoko Matsumoto, Yutaka Shimada, Tohru Ikeguchi in Scientific Reports (2023)

  2. No Access

    Chapter and Conference Paper

    Analysis of Synchronization of Mechanical Metronomes

    Synchronization phenomena are ubiquitous around us and are observed in various real systems, for example, hands clap** (rhythmic applause) at the concert hall, light emission of fireflies, callings of frogs,...

    Tohru Ikeguchi, Yutaka Shimada in Proceedings of the 5th International Confe… (2019)

  3. Article

    Open Access

    Highly efficient capture of cancer cells expressing EGFR by microfluidic methods based on antigen-antibody association

    Epidermal growth factor receptor (EGFR) was evaluated as a target antigen for cancer cell capture by microfluidic methods based on antigen-antibody association. A polymer CTC-chip microfluidic device was surfa...

    Takashi Ohnaga, Yoshinori Takei, Takuya Nagata, Yutaka Shimada in Scientific Reports (2018)

  4. No Access

    Chapter

    Clinical Application of Stem Cell Biology in Esophageal Cancer

    Despite recent progress in its diagnosis and multimodal therapies, prognosis in patients with esophageal squamous cell carcinoma (ESCC) remains poor, because of high incidence of metastasis and therapeutic res...

    Tomoyuki Okumura, Hirohumi Kojima in Molecular Diagnosis and Targeting for Thor… (2018)

  5. Article

    Open Access

    Patient safety incident reports related to traditional Japanese Kampo medicines: medication errors and adverse drug events in a university hospital for a ten-year period

    Kampo medicine is traditional Japanese medicine, which originated in ancient traditional Chinese medicine, but was introduced and developed uniquely in Japan. Today, Kampo medicines are integrated into the Jap...

    Yutaka Shimada, Makoto Fujimoto in BMC Complementary and Alternative Medicine (2017)

  6. Article

    Open Access

    Reproducing Infra-Slow Oscillations with Dopaminergic Modulation

    In the human brain, billions of neurons construct a neural network via synaptic connections. Neuronal excitation and inhibition are transmitted to other neurons through synapses via neurotransmitters. Dopamine...

    Toshihiro Kobayashi, Yutaka Shimada, Kantaro Fujiwara, Tohru Ikeguchi in Scientific Reports (2017)

  7. Article

    Open Access

    Erratum to: Carbon ion radiotherapy for desmoid tumor of the abdominal wall: a case report

    Takuya Nagata, Yusuke Demizu, Tomoyuki Okumura in World Journal of Surgical Oncology (2017)

  8. No Access

    Article

    KLF4 and NANOG are prognostic biomarkers for triple-negative breast cancer

    Prognosis of breast cancer patients has been reported to depend on the expression of induced pluripotent stem (iPS) cell-inducing factors: KLF4 and NANOG. However, the relationship between KLF4 or NANOG expres...

    Takuya Nagata, Yutaka Shimada, Shinichi Sekine, Makoto Moriyama in Breast Cancer (2017)

  9. No Access

    Chapter

    Clinical Relevance of a Candidate Stem Cell Marker, p75 Neurotrophin Receptor (p75NTR) Expression in Circulating Tumor Cells

    Despite advances in its diagnosis and multimodal therapies, the of esophageal squamous cell carcinoma (ESCC) patients remains poor, because of high incidences of . Recent reports suggested that circulating ...

    Tomoyuki Okumura, Tetsuji Yamaguchi in Isolation and Molecular Characterization o… (2017)

  10. No Access

    Reference Work Entry In depth

    Bile Acids

    Toshiya Soma, Yutaka Shimada in Encyclopedia of Cancer (2017)

  11. No Access

    Protocol

    Flow Cytometric Detection of Circulating Tumor Cells Using a Candidate Stem Cell Marker, p75 Neurotrophin Receptor (p75NTR)

    The most widely studied detection for circulating tumor cells (CTCs) in peripheral blood of cancer patients has been based on immunomagnetic enrichment using antibodies against epithelial cell adhesion molecul...

    Tomoyuki Okumura M.D., Ph.D., Tetsuji Yamaguchi, Toru Watanabe in Circulating Tumor Cells (2017)

  12. Article

    Open Access

    Graph distance for complex networks

    Networks are widely used as a tool for describing diverse real complex systems and have been successfully applied to many fields. The distance between networks is one of the most fundamental concepts for prope...

    Yutaka Shimada, Yoshito Hirata, Tohru Ikeguchi, Kazuyuki Aihara in Scientific Reports (2016)

  13. Article

    Open Access

    Carbon ion radiotherapy for desmoid tumor of the abdominal wall: a case report

    Desmoid tumors, which are associated with familial adenomatous polyposis (FAP), tend to occur frequently in the abdominal wall and mesentery. Currently, there are no recognized treatments other than surgery, a...

    Takuya Nagata, Yusuke Demizu, Tomoyuki Okumura in World Journal of Surgical Oncology (2016)

  14. Article

    Open Access

    The expression of microRNA 574-3p as a predictor of postoperative outcome in patients with esophageal squamous cell carcinoma

    Despite advances in radical esophagectomies and adjuvant therapy, the postoperative prognosis in esophageal squamous cell carcinoma (ESCC) patients remains poor. The aim of this study was to identify a molecul...

    Tomoyuki Okumura, Hirohumi Kojima, Takeshi Miwa in World Journal of Surgical Oncology (2016)

  15. No Access

    Article

    Functional outcome assessment of swallowing (FOAMS) scoring and videofluoroscopic evaluation of perioperative swallowing rehabilitation in radical esophagectomy

    Oropharyngeal swallowing dysfunction following esophagectomy has been associated with the surgical disruption of muscle strength and flexibility of the oropharyngeal structures. We assessed the value of periop...

    Tomoyuki Okumura, Yutaka Shimada, Toru Watanabe, Naomi Nakamichi in Surgery Today (2016)

  16. No Access

    Article

    Endoscopic thyroidectomy using the EZ-VANS method

    Several video-assisted and robotic surgery techniques have been reported for resection of the thyroid and parathyroid glands. Our institute has started performing endoscopic thyroidectomy using the Lap-protect...

    Takuya Nagata, Yutaka Shimada, Takeshi Miwa, Isaya Hashimoto in Surgery Today (2016)

  17. No Access

    Article

    The renoprotective effect of shichimotsukokato on hypertension-induced renal dysfunction in spontaneously hypertensive rats

    Antihypertensive treatment is highly important to prevent the progression of chronic kidney disease. Shichimotsukokato (SKT), a traditional Japanese medicine (i.e., Kampo formula), lowered systolic blood press...

    Yue Ma, Makoto Fujimoto, Hidetoshi Watari, Mari Kimura in Journal of Natural Medicines (2016)

  18. Article

    Open Access

    Detection of circulating tumor cells by p75NTR expression in patients with esophageal cancer

    The p75 neurotrophin receptor (p75NTR) is a cancer stem cell (CSC) marker in esophageal squamous cell carcinoma (ESCC). This study aimed to assess the use of p75NTR in detecting circulating tumor cells (CTCs) ...

    Tetsuji Yamaguchi, Tomoyuki Okumura, Katsuhisa Hirano in World Journal of Surgical Oncology (2016)

  19. No Access

    Article

    Role of fibroblast growth factor receptors in esophageal squamous cell carcinoma

    We previously reported that the expression of fibroblast growth factor receptor-like 1 (FGFRL1) was associated with the progression of esophageal squamous cell carcinoma (ESCC). However, the clinical roles of ...

    Yutaka Shimada, Tomoyuki Okumura, Yoshinori Takei, Kazuaki Watanabe in Esophagus (2016)

  20. No Access

    Article

    Left brachiocephalic vein injury during esophagectomy

    Left brachiocephalic vein injury has not yet been reported during reconstruction after esophagectomy. A 58-year-old male patient was diagnosed with cervical esophageal squamous cell carcinoma and subsequently ...

    Yutaka Shimada, Tomoyuki Okumura, Isaya Hashimoto, Takuya Nagata in Esophagus (2015)

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