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  1. No Access

    Article

    Molecular mechanism of antidiabetic zinc–allixin complexes: regulations of glucose utilization and lipid metabolism

    We previously reported new zinc complexes of allixin [bis(allixinato)zinc] and its derivative bis(thioallixin-N-methyl)zinc that demonstrated excellent antidiabetic activity in type 2 diabetic mellitus KKAy mice....

    Akihiro Nakayama, Makoto Hiromura… in JBIC Journal of Biological Inorganic Chemi… (2008)

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    Article

    Action mechanism of bis(allixinato)oxovanadium(IV) as a novel potent insulin-mimetic complex: regulation of GLUT4 translocation and FoxO1 transcription factor

    Bis(allixinato)oxovanadium(IV), VO(alx)2 (alx is 3-hydroxy-5-methoxy-6-methyl-2-pentyl-4-pyrone), has been reported to act as an antidiabetic agent in streptozotocin-induced type-1-like and obesity-linked KKAy ty...

    Makoto Hiromura, Akihiro Nakayama… in JBIC Journal of Biological Inorganic Chemi… (2007)

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    Article

    Metallokinetic characteristics of antidiabetic bis(allixinato)oxovanadium(IV)-related complexes in the blood of rat

    The antidiabetic effect of vanadium is a widely accepted phenomenon; some oxovanadium(IV) complexes have been found to normalize high blood glucose levels in both type 1 and type 2 diabetic animals. In light o...

    Hiroyuki Yasui, Yusuke Adachi, Akira Katoh… in JBIC Journal of Biological Inorganic Chemi… (2007)

  4. No Access

    Article

    Isolation of a bacterium that degrades urethane compounds and characterization of its urethane hydrolase

    A bacterium which degrades urethane compounds was isolated and identified as Rhodococcus equi strain TB-60. Strain TB-60 degraded toluene-2,4-dicarbamic acid dibutyl ester (TDCB) and accumulated toluene diamine a...

    Yukie Akutsu-Shigeno, Yusuke Adachi, Chise Yamada… in Applied Microbiology and Biotechnology (2006)

  5. No Access

    Article

    The Pharmacology of the Insulinomimetic Effect of Zinc Complexes

    In develo** new insulinomimetic zinc(II) complexes with different coordination structures and with a blood glucose-lowering effect to treat type 2 diabetic animals, we found a potent bis(maltolato)zinc(ll) c...

    Hiromu Sakurai, Yusuke Adachi in Biometals (2005)

  6. No Access

    Article

    A new insulin-mimetic bis(allixinato)zinc(II) complex: structure–activity relationship of zinc(II) complexes

    During the investigation of the development of insulin-mimetic zinc(II) complexes with a blood glucose-lowering effect in experimental diabetic animals, we found a potent bis(maltolato)zinc(II) complex, Zn(ma)2, ...

    Yusuke Adachi, Jiro Yoshida, Yukihiro Kodera… in JBIC Journal of Biological Inorganic Chemi… (2004)