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  1. No Access

    Article

    Molecular mechanism of antidiabetic zinc–allixin complexes: regulations of glucose utilization and lipid metabolism

    We previously reported new zinc complexes of allixin [bis(allixinato)zinc] and its derivative bis(thioallixin-N-methyl)zinc that demonstrated excellent antidiabetic activity in type 2 diabetic mellitus KKAy mice....

    Akihiro Nakayama, Makoto Hiromura… in JBIC Journal of Biological Inorganic Chemi… (2008)

  2. No Access

    Article

    Action mechanism of bis(allixinato)oxovanadium(IV) as a novel potent insulin-mimetic complex: regulation of GLUT4 translocation and FoxO1 transcription factor

    Bis(allixinato)oxovanadium(IV), VO(alx)2 (alx is 3-hydroxy-5-methoxy-6-methyl-2-pentyl-4-pyrone), has been reported to act as an antidiabetic agent in streptozotocin-induced type-1-like and obesity-linked KKAy ty...

    Makoto Hiromura, Akihiro Nakayama… in JBIC Journal of Biological Inorganic Chemi… (2007)

  3. No Access

    Article

    Metallokinetic characteristics of antidiabetic bis(allixinato)oxovanadium(IV)-related complexes in the blood of rat

    The antidiabetic effect of vanadium is a widely accepted phenomenon; some oxovanadium(IV) complexes have been found to normalize high blood glucose levels in both type 1 and type 2 diabetic animals. In light o...

    Hiroyuki Yasui, Yusuke Adachi, Akira Katoh… in JBIC Journal of Biological Inorganic Chemi… (2007)

  4. No Access

    Article

    The Pharmacology of the Insulinomimetic Effect of Zinc Complexes

    In develo** new insulinomimetic zinc(II) complexes with different coordination structures and with a blood glucose-lowering effect to treat type 2 diabetic animals, we found a potent bis(maltolato)zinc(ll) c...

    Hiromu Sakurai, Yusuke Adachi in Biometals (2005)

  5. No Access

    Article

    A new insulin-mimetic bis(allixinato)zinc(II) complex: structure–activity relationship of zinc(II) complexes

    During the investigation of the development of insulin-mimetic zinc(II) complexes with a blood glucose-lowering effect in experimental diabetic animals, we found a potent bis(maltolato)zinc(II) complex, Zn(ma)2, ...

    Yusuke Adachi, Jiro Yoshida, Yukihiro Kodera… in JBIC Journal of Biological Inorganic Chemi… (2004)