6 Result(s)

Article

Proteomic analysis across patient iPSC-based models and human post-mortem hippocampal tissue reveals early cellular dysfunction and progression of Alzheimer’s disease pathogenesis

The hippocampus is a primary region affected in Alzheimer’s disease (AD). Because AD postmortem brain tissue is not available prior to symptomatic stage, we lack understanding of early cellular pathogenic mech...

Yuriy Pomeshchik, Erika Velasquez, Jeovanis Gil… in Acta Neuropathologica Communications (2023)

Article

An arylthiazyne derivative is a potent inhibitor of lipid peroxidation and ferroptosis providing neuroprotection in vitro and in vivo

Lipid peroxidation-initiated ferroptosis is an iron-dependent mechanism of programmed cell death taking place in neurological diseases. Here we show that a condensed benzo[b]thiazine derivative small molecule ...

Meike Hedwig Keuters, Velta Keksa-Goldsteine, Hiramani Dhungana… in Scientific Reports (2021)

Article

The Copper bis(thiosemicarbazone) Complex Cu^II(atsm) Is Protective Against Cerebral Ischemia Through Modulation of the Inflammatory Milieu

Develo** new therapies for stroke is urgently needed, as this disease is the leading cause of death and disability worldwide, and the existing treatment is only available for a small subset of patients. The ...

Mikko T. Huuskonen, Qing-zhang Tuo, Sanna Loppi, Hiramani Dhungana… in Neurotherapeutics (2017)

Article

Erratum to: ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis

Sighild Lemarchant, Yuriy Pomeshchik, Iurii Kidin… in Molecular Neurodegeneration (2016)

Article

ADAMTS-4 promotes neurodegeneration in a mouse model of amyotrophic lateral sclerosis

A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) proteoglycanases are specialized in the degradation of chondroitin sulfate proteoglycans and participate in mechanisms mediating neuropla...

Sighild Lemarchant, Yuriy Pomeshchik, Iurii Kidin… in Molecular Neurodegeneration (2016)

Article

Effects of human intravenous immunoglobulin on amyloid pathology and neuroinflammation in a mouse model of Alzheimer’s disease

Human intravenous immunoglobulin (hIVIG) preparation is indicated for treating primary immunodeficiency disorders associated with impaired humoral immunity. hIVIG is known for its anti-inflammatory properties ...

Lakshman Puli, Yuriy Pomeshchik, Katja Olas, Tarja Malm… in Journal of Neuroinflammation (2012)