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Article
Open AccessAdvancing Guideline-Directed Medical Therapy in Heart Failure: Overcoming Challenges and Maximizing Benefits
The delayed titration of guideline-directed drug therapy (GDMT) is a complex event influenced by multiple factors that often result in poor prognosis for patients with heart failure (HF). Individualized adjust...
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Article
Open AccessOvercoming barriers for left atrial appendage thrombus: a systematic review of left atrial appendage closure
Approximately 90% of intracardial thrombi originate from the left atrial appendage in non-valvular atrial fibrillation patients. Even with anticoagulant therapy, left atrial appendage thrombus (LAAT) still occ...
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Article
Open AccessAmino acid profile alteration in age-related atrial fibrillation
Amino acids (AAs) are one of the primary metabolic substrates for cardiac work. The correlation between AAs and both atrial fibrillation (AF) and aging has been documented. However, the relationship between AA...
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Article
Open AccessThe desmosomal cadherin desmoglein-3 acts as a keratinocyte anti-stress protein via suppression of p53
Desmoglein-3 (Dsg3), the Pemphigus Vulgaris (PV) antigen (PVA), plays an essential role in keratinocyte cell–cell adhesion and regulates various signaling pathways involved in the progression and metastasis of ca...