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Novel Drug Targets for Atrial Fibrillation Identified Through Mendelian Randomization Analysis of the Blood Proteome

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  1. Article

    Open Access

    Advancing Guideline-Directed Medical Therapy in Heart Failure: Overcoming Challenges and Maximizing Benefits

    The delayed titration of guideline-directed drug therapy (GDMT) is a complex event influenced by multiple factors that often result in poor prognosis for patients with heart failure (HF). Individualized adjust...

    Zixi Zhang, Cancan Wang, Tao Tu, Qiuzhen Lin in American Journal of Cardiovascular Drugs (2024)

  2. Article

    Open Access

    Overcoming barriers for left atrial appendage thrombus: a systematic review of left atrial appendage closure

    Approximately 90% of intracardial thrombi originate from the left atrial appendage in non-valvular atrial fibrillation patients. Even with anticoagulant therapy, left atrial appendage thrombus (LAAT) still occ...

    Zixi Zhang, Jiabao Zhou, Qiuzhen Lin, Cancan Wang in BMC Cardiovascular Disorders (2024)

  3. Article

    Open Access

    Amino acid profile alteration in age-related atrial fibrillation

    Amino acids (AAs) are one of the primary metabolic substrates for cardiac work. The correlation between AAs and both atrial fibrillation (AF) and aging has been documented. However, the relationship between AA...

    Yunying Huang, Qiuzhen Lin, Yong Zhou, Jiayi Zhu in Journal of Translational Medicine (2024)

  4. Article

    Open Access

    The desmosomal cadherin desmoglein-3 acts as a keratinocyte anti-stress protein via suppression of p53

    Desmoglein-3 (Dsg3), the Pemphigus Vulgaris (PV) antigen (PVA), plays an essential role in keratinocyte cell–cell adhesion and regulates various signaling pathways involved in the progression and metastasis of ca...

    Ambreen Rehman, Yang Cai, Christian Hünefeld, Hana Jedličková in Cell Death & Disease (2019)