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Article
H4S47 O-GlcNAcylation regulates the activation of mammalian replication origins
The transmission and maintenance of genetic information in eukaryotic cells relies on the faithful duplication of the entire genome. In each round of division, excessive replication origins are licensed, with ...
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Article
Macroscopic experimental and constitutive model research on tensile properties of sandstone after high-temperature treatment
The physical and mechanical properties of the surrounding rock on the geothermal wellbore will be deteriorated by high temperature, resulting in reduced stability. In order to investigate the tensile propertie...
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Article
Experimental investigation on the seepage characteristics and temperature–permeability (T–P) model of sandstone after different temperature treatments
In order to study the effect of high temperature on the permeability characteristics of the surrounding rock of the geothermal well, the steady-state method was used to conduct experiments on the permeability ...
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Article
Regulation of Tumor Suppressor Gene CDKN2A and Encoded p16-INK4a Protein by Covalent Modifications
CDKN2A is one of the most studied tumor suppressor genes. It encodes the p16-INK4a protein that plays a critical role in the cell cycle progression, differentiation, senescence, and apoptosis. Mutations in CDKN2A
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Article
Lewis-antigen-containing ICAM-2/3 on Jurkat leukemia cells interact with DC-SIGN to regulate DC functions
Dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN) is an important C-type lectin and plays a critical role in the recognition of pathogens and self-antigens. It has recent...
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Article
Optical design of rectangular illumination with freeform lenses for the application of LED road lighting
We present a freeform lens for application to light-emitting diodes (LED) road lighting. We propose a simple source–target luminous intensity map** method based on Snell’s law and geometric-optics analysis. ...
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Article
Investigation of electrorheological fluid for optical finishing
Electrorheological (ER) finishing is a promising technique for polishing optical mirrors lenses. Silicone oil-based ER finishing fluid with ceria particles as abrasive was developed, whose dispersed phase was ...
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Article
Magnetorheological finishing of optical surface combined with symmetrical tool function
This research is aimed at the development of computer-aided polishing technology for optical surfaces using magnetorheological (MR) fluid as medium. The mechanism of a dual-axis polishing wheel and the mathema...
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Article
Method of optical interference testing error separation
During the testing of aspherical mirrors through the null compensation method, structural parameters observe changes which affect the test results of interference pattern. Several errors are induced due to the...
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Article
The proximal GC-rich region of p16INK4a gene promoter plays a role in its transcriptional regulation
p16INK4a plays a key role in control of cell cycle progression by negatively regulating the CDK4/6 activity. This study establishes that the p16INK4a minimal promoter region required for the transcription factor ...
