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Article
Open AccessACLS4 could be a potential therapeutic target for severe acute pancreatitis
Acute pancreatitis (AP) is currently among the most prevalent digestive diseases. The pathogenesis of AP remains elusive, and there is no specific treatment. Therefore, identifying novel therapeutic targets is...
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Article
Open AccessCEP20 promotes invasion and metastasis of non-small cell lung cancer cells by depolymerizing microtubules
Worldwide, Lung cancer is the leading cause of cancer-related death and poses a direct health threat, non-small cell lung cancer (NSCLC) is the most common type. In this study, we demonstrated that centrosomal...
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Article
A fast chemical reprogramming system promotes cell identity transition through a diapause-like state
Cellular reprogramming by only small molecules holds enormous potentials for regenerative medicine. However, chemical reprogramming remains a slow process and labour intensive, hindering its broad applications...
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Article
Open AccessN6-methyladenosine modification-mediated mRNA metabolism is essential for human pancreatic lineage specification and islet organogenesis
Pancreatic differentiation from human pluripotent stem cells (hPSCs) provides promising avenues for investigating development and treating diseases. N6-methyladenosine (m6A) is the most prevalent internal messeng...
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Article
Open AccessMiR-93 suppresses tumorigenesis and enhances chemosensitivity of breast cancer via dual targeting E2F1 and CCND1
Chemoresistance of tumors often leads to treatment failure in clinical practice, which underscores pivotal needs to uncover novel therapeutic strategies. Accumulating evidences show that microRNAs (miRNAs) are...
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Article
Effect of Phosphating and Heat Treatment on Magnetic Properties of Fe-3.3Si-6.5Cr Soft Magnetic Composites
Fe-3.3Si-6.5Cr powders were first treated by phosphoric acid solution and then mixed with epoxy-modified silicone resin uniformly, forming insulation coating. The Fe-3.3Si-6.5Cr soft magnetic composites were p...
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Article
Open AccessExploring specific prognostic biomarkers in triple-negative breast cancer
Lacking of both prognostic biomarkers and therapeutic targets, triple-negative breast cancer (TNBC) underscores pivotal needs to uncover novel biomarkers and viable therapies. MicroRNAs have broad biological f...
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Article
Open AccessNudC-like protein 2 restrains centriole amplification by stabilizing HERC2
Centriole duplication is tightly controlled to occur once per cell cycle, and disruption of this synchrony causes centriole amplification, which is frequently observed in many cancers. Our previous work showed...
