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Article
Open AccessElevated plasma neurofilament light was associated with multi-modal neuroimaging features in Alzheimer’s disease signature regions and predicted future tau deposition
Neurofilament Light (NfL) is a biomarker for early neurodegeneration in Alzheimer’s disease (AD). This study aims to examine the association between plasma NfL and multi-modal neuroimaging features across the ...
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Article
Open AccessThe impact of an innovative payment method on medical expenditure, efficiency, and quality for inpatients with different types of medical insurance: evidence from a pilot city, China
Since 2020, China has implemented an innovative payment method called Diagnosis-Intervention Packet (DIP) in 71 cities nationwide. This study aims to assess the impact of DIP on medical expenditure, efficiency...
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Article
Salt-assisted vapor–liquid–solid growth of high-quality ultrathin nickel oxide flakes for artificial synapses in image recognition applications
Transition metal oxides have attracted intense interest owing to their abundant physical and chemical properties. The controlled preparation of large-area, high-quality two-dimensional crystals is essential fo...
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Article
Operational Characteristics of Loop Heat Pipe in Microgravity and Normal Gravity Environments
The loop heat pipe (LHP) is an advanced, efficient two-phase heat transfer unit, whose operational performance may be affected by microgravity conditions in contrast to ground-based applications. The performan...
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Article
Open AccessEffects of the kinetic pattern of dietary glucose release on nitrogen utilization, the portal amino acid profile, and nutrient transporter expression in intestinal enterocytes in piglets
Promoting the synchronization of glucose and amino acid release in the digestive tract of pigs could effectively improve dietary nitrogen utilization. The rational allocation of dietary starch sources and the ...
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Article
Open AccessDevelopment of a CRISPR-Cas12a based assay for the detection of swine enteric coronaviruses in pig herds in China
Porcine epidemic diarrhea virus (PEDV), Transmissible gastroenteritis virus (TGEV), Porcine deltacoronavirus (PDCoV) and Swine acute diarrhea syndrome coronavirus (SADS-CoV) rank among the most frequently enco...
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Article
Molecular Mechanisms of Male Sterility in Maize
Maize (Zea mays) represents one of the most successful uses of heterosis among crops. Hybrid maize seeds can be produced by crossing a male-sterile female parent with a male parent as the pollen donor to achieve ...
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Article
Use of extreme gradient boosting, light gradient boosting machine, and deep neural networks to evaluate the activity stage of extraocular muscles in thyroid-associated ophthalmopathy
To develop a machine learning model to evaluate the activity stage of extraocular muscles in thyroid-associated ophthalmopathy (TAO).
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Article
Femtosecond laser-induced periodic surface structures on hard and brittle materials
Hard and brittle materials have high hardness, excellent optical stability, chemical stability, and high thermal stability. Hence, they have huge application potential in various fields, such as optical compon...
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Article
Immunotherapy Guided by Immunohistochemistry PD-L1 Testing for Patients with NSCLC: A Microsimulation Model-Based Effectiveness and Cost-Effectiveness Analysis
On the basis of immunohistochemistry PD-L1 testing results, patients with advanced non-small cell lung cancer (NSCLC) are treated differently. Theoretically, patients with high PD-L1 expression (50% or 1%) sho...
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Article
Pyroptosis in microbial infectious diseases
Pyroptosis is a gasdermins-mediated programmed cell death that plays an essential role in immune regulation, and its role in autoimmune disease and cancer has been studied extensively. Increasing evidence show...
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Article
Open AccessUntargeted serum metabolomics reveals potential biomarkers and metabolic pathways associated with the progression of gastroesophageal cancer
Previous metabolic studies in upper digestive cancer have mostly been limited to cross-sectional study designs, which hinders the ability to effectively predict outcomes in the early stage of cancer. This stud...
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Article
Open AccessCirculating cell-free DNA fragmentation is a stepwise and conserved process linked to apoptosis
Circulating cell-free DNA (cfDNA) is a pool of short DNA fragments mainly released from apoptotic hematopoietic cells. Nevertheless, the precise physiological process governing the DNA fragmentation and molecu...
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Article
Open AccessGenerative adversarial network for unsupervised multi-lingual knowledge graph entity alignment
Entity alignment is an essential process in knowledge graph (KG) fusion, which aims to link entities representing the same real-world object in different KGs, to achieve entity expansion and graph fusion. Rece...
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Article
Quickly assessing disinfection effectiveness to control the spread of African swine fever virus
Infectious African swine fever virus (ASFV) can cause the spread and morbidity of African swine fever, while the inactivated virus cannot. When they are not distinguished separately, the detection results will...
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Article
Open AccessHypnotics and injuries among older adults with Parkinson’s disease: a nested case–control design
Patients with Parkinson’s disease often experience sleep disorders. Hypnotics increase the risk of adverse events, such as injuries due to falls. In this study, we evaluated the association between hypnotics a...
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Article
[68Ga]Ga-FAPI PET for the evaluation of digestive system tumors: systematic review and meta-analysis
Digestive system tumors are a group of tumors with high incidence in the world nowadays. The assessment of digestive system tumor metastasis by conventional imaging seems to be unsatisfactory. [68Ga]Ga-FAPI, whic...
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Article
Open AccessThe collateral activity of RfxCas13d can induce lethality in a RfxCas13d knock-in mouse model
The CRISPR-Cas13 system is an RNA-guided RNA-targeting system and has been widely used in transcriptome engineering with potentially important clinical applications. However, it is still controversial whether ...
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Article
Exosomal circ_0091741 promotes gastric cancer cell autophagy and chemoresistance via the miR-330-3p/TRIM14/Dvl2/Wnt/β-catenin axis
The importance of cancer cell-released exosomes in the treatment of various cancers has been well-characterized. The current study aims to examine the potential biological functions of gastric cancer (GC) cell...
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Article
Dynamic characteristic reconfiguration of a fixture-workpiece system for vibration suppression in milling of thin-walled workpieces based on MR dam** fixture
Milling of the low rigidity and large deformation thin-walled workpiece is a critical challenging task due to the obvious machining vibration, which greatly affects the machining accuracy and surface quality o...
