32 Result(s)

Article

Identification of 1-(thiophene-2-carbonyl)-LSD from blotter paper falsely labeled “1D-LSD”

Since the mid-2010s, lysergic acid diethylamide (LSD) analogs made for substance abuse have periodically emerged. In this case, three pieces of blotter paper labeled “1D-LSD” and presumably impregnated with th...

Yuki Okada, Kazuki Ueno, Noriko Nishiwaki, Toshihiko Nishimura… in Forensic Toxicology (2024)

Article

Identifying a suspect powder as a cannabis concentrate through chemical analysis and DNA testing

Cannabis is regulated in many countries, and cannabis products are diversifying, which can hinder identification. Here, we report the seizure of a powder sample with a cannabis-like odor in a spice bottle labe...

Tadashi Yamamuro, Yusuke Saito, Yuki Okada, Hiroki Segawa… in Forensic Toxicology (2024)

Article

Evaluation of applicability of micro-segmental analysis to hair treated with heat and haircare products

Micro-segmental analysis (MSA), which enables the measurement of detailed drug distributions in hair by segmenting a single hair strand at 0.4 mm intervals, is indispensable for estimating the day of drug inge...

Kenji Kuwayama, Hajime Miyaguchi, Tatsuyuki Kanamori… in Forensic Toxicology (2023)

Article

Short-term stability of a small amount of neat Δ⁹-tetrahydrocannabinol

Kenji Tsujikawa, Yuki Okada, Hiroki Segawa, Tadashi Yamamuro… in Forensic Toxicology (2023)

Article

Evaluation of decarboxylation efficiency of Δ⁹-tetrahydrocannabinolic acid and cannabidiolic acid by UNODC method

Decarboxylation of Δ⁹-tetrahydrocannabinolic acid (Δ⁹-THCA) to Δ⁹-tetrahydrocannabinol (Δ⁹-THC) by heating is a common method for determining total Δ⁹-THC. In the manual for cannabis identification and analysis, ...

Kenji Tsujikawa, Yuki Okada, Hiroki Segawa, Tadashi Yamamuro… in Forensic Toxicology (2023)

Article

Possibility of drug-distribution measurement in the hair of drowned bodies: evaluation of drug stability in water-soaked hair using micro-segmental analysis

In postmortem examinations, the drug analysis of hair is effective for revealing drug-use history. Additionally, a method to estimate the day of death using hair was previously developed by analyzing a single ...

Kenji Kuwayama, Hajime Miyaguchi… in International Journal of Legal Medicine (2023)

Article

Thin-layer chromatography on silver nitrate-impregnated silica gel for analysis of homemade tetrahydrocannabinol mixtures

Various forms of cannabidiol (CBD)-containing products are sold in Japan. CBD is easily converted to mixtures of ∆⁹-tetrahydrocannabinol (∆⁹-THC) and its isomer, ∆⁸-THC, using household chemicals like diluted hyd...

Kenji Tsujikawa, Yuki Okada, Hiroki Segawa, Tadashi Yamamuro… in Forensic Toxicology (2022)

Article

Agonistic activity of fentanyl analogs and their metabolites on opioid receptors

This study aims to expose the toxicity of fentanyl analogs and their metabolites by measuring the agonistic activity of these compounds on opioid receptors.

Tatsuyuki Kanamori, Yuki Okada, Hiroki Segawa, Tadashi Yamamuro… in Forensic Toxicology (2022)

Article

Degradation of 1-phenyl-2-propanone during long-term storage: useful information for methamphetamine impurity profiling

1-Phenyl-2-propanone (P2P) is a main precursor of methamphetamine. The authors investigated the formation of P2P degradation products during long-term storage and the factors that affected P2P degradation.

Kenji Tsujikawa, Yuki Okada, Hiroki Segawa, Tadashi Yamamuro… in Forensic Toxicology (2021)

Article

DNA testing of suspected cannabis samples with exceptional morphology using a simple detection kit

Cannabis is the most abused drug in the world and molecular biology techniques for the analysis of cannabis have attracted attention in recent years. We report a case of three persons conspiring to possess can...

Tadashi Yamamuro, Yukie Iwai, Maho Kawamura, Akihiro Nakamoto… in Forensic Toxicology (2021)

Article

Development of the “selective concentration” analytical method for drug-containing hair regions based on micro-segmental analysis to identify a trace amount of drug in hair: hair analysis following single-dose ingestion of midazolam

Hair can be the only available specimen to prove drug-facilitated crimes (DFCs). However, it is difficult to identify drugs abused in DFCs, particularly benzodiazepines ingested in a single dose, using the con...

Kenji Kuwayama, Hajime Miyaguchi, Tatsuyuki Kanamori… in Forensic Toxicology (2021)

Article

Phosgene in deteriorated chloroform: presumptive cause of production of 3,4-dimethyl-5-phenyl-2-oxazolidones in methamphetamine

The trans- and cis-forms of 3,4-dimethyl-5-phenyl-2-oxazolidone (DPO) are impurities found in methamphetamine, but their production mechanism has been unclear. Here, the authors examined whether DPOs were produce...

Kenji Tsujikawa, Hiroki Segawa, Kenji Kuwayama, Tadashi Yamamuro… in Forensic Toxicology (2020)

Article

Strong evidence of drug-facilitated crimes by hair analysis using LC–MS/MS after micro-segmentation

Hair analysis can provide effective information to prove drug-facilitated crimes (DFCs). Herein, an analytical procedure for obtaining evidence of DFCs stronger than with conventional segmental hair analysis i...

Kenji Kuwayama, Hajime Miyaguchi, Yuko T. Iwata, Tatsuyuki Kanamori… in Forensic Toxicology (2019)

Article

Estimation of day of death using micro-segmental hair analysis based on drug use history: a case of lidocaine use as a marker

During investigations of unnatural death, the time of death is generally estimated using anatomical examinations. However, it can be difficult to accurately determine the day of death, because postmortem chang...

Kenji Kuwayama, Maika Nariai, Hajime Miyaguchi… in International Journal of Legal Medicine (2019)

Article

Simultaneous chiral impurity analysis of methamphetamine and its precursors by supercritical fluid chromatography–tandem mass spectrometry

Impurity profiling of seized illicit methamphetamine (MA) provides information on MA manufacturing methods in clandestine laboratories, and this drug intelligence supports formulation of strategies to control ...

Hiroki Segawa, Yuko T. Iwata, Tadashi Yamamuro, Kenji Kuwayama… in Forensic Toxicology (2019)