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    Antitumor effects of minodronate, a third-generation nitrogen-containing bisphosphonate, in synergy with γδT cells in human glioblastoma in vitro and in vivo

    Nitrogen-containing bisphosphonates (N-BPs), which prevent bone resorption, exert direct and γδT cell (GDT)-mediated antitumor effects against several tumor cell types, including glioblastoma (GBM). However, l...

    Tsutomu Nakazawa, Mitsutoshi Nakamura, Ryosuke Matsuda in Journal of Neuro-Oncology (2016)

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    Cytotoxic human peripheral blood-derived γδT cells kill glioblastoma cell lines: implications for cell-based immunotherapy for patients with glioblastoma

    Glioblastoma (GBM) is a highly aggressive brain tumor for which novel therapeutic approaches, such as immunotherapy, are urgently needed. Zoledronate (ZOL), an inhibitor of osteoclastic activity, is known to s...

    Tsutomu Nakazawa, Mitsutoshi Nakamura, Young Soo Park in Journal of Neuro-Oncology (2014)