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Article
HLA haploidentical stem cell transplantation from HLA homozygous donors to HLA heterozygous donors may have lower survival rates than haploidentical transplantation from HLA heterozygous donors to HLA heterozygous donors: a retrospective nationwide analysis
In HLA haploidentical stem cell transplantation, patients and donors usually share one HLA haplotype and have one different HLA haplotype (hetero-to-hetero). However, there are rare cases of transplantation fr...
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Article
Open AccessImmunoreactivity to WT1 peptide vaccine is associated with prognosis in elderly patients with acute myeloid leukemia: follow-up study of randomized phase II trial of OCV-501, an HLA class II-binding WT1 polypeptide
We previously conducted a randomized phase II trial of OCV-501, a WT1 peptide presented by helper T cells, in elderly AML (acute myeloid leukemia) patients in first remission, indicating no difference in 2-yea...
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Article
Coombs’ test positive autoimmune hemolytic anemia accompanied by myelodysplastic syndrome that became Coombs’ test negative after azacitidine administration
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Article
Effectiveness of hyperbaric oxygen therapy for virus-associated hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation
Although some studies have suggested the effectiveness of hyperbaric oxygen (HBO) therapy for hemorrhagic cystitis (HC) after allogeneic hematopoietic stem cell transplantation (HSCT), the role of HBO has not ...
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Article
Pembrolizumab plus lenalidomide and dexamethasone in treatment-naive multiple myeloma (KEYNOTE-185): subgroup analysis in Japanese patients
The global, randomized, open-label KEYNOTE-185 study closed early after an interim analysis showed an unfavorable benefit-risk profile with pembrolizumab plus lenalidomide and low-dose dexamethasone (Rd) versu...
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Article
Two unique HLA-A*0201 restricted peptides derived from cyclin E as immunotherapeutic targets in leukemia
Immunotherapy targeting leukemia-associated antigens has shown promising results. Because of the heterogeneity of leukemia, vaccines with a single peptide have elicited only a limited immune response. Targetin...
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Article
Late response to low-dose imatinib in patients with chronic phase chronic myeloid leukemia
Imatinib was the first BCR-ABL tyrosine kinase inhibitor to become clinically available. In this study, we retrospectively evaluated the long-term efficacy of low-dose imatinib (final maintenance dose <300 mg ...
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Article
TGF-β–FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia
Chronic myeloid leukaemia (CML) is caused by a BCR-ABL fusion that generates a constitutively active tyrosine kinase. Although inhibition of tyrosine kinase with imatinib has been used successfully for CML the...
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Article
Erratum to: Cord blood transplantation using minimum conditioning regimens for patients with hematologic malignancies complicated by severe infections
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Article
Cord blood transplantation using minimum conditioning regimens for patients with hematologic malignancies complicated by severe infections
Patients with severe infections are thought to be ineligible for cord blood stem cell transplantation (CBT) because the conventional 5–6 day-conditioning regimens potentially makes them susceptible to fatal in...
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Article
Living-Donor Lobar Lung Transplantation for Broncho-Bronchiolitis Obliterans after Allogeneic Hematopoietic Stem Cell Transplantation: Does Bronchiolitis Obliterans Recur in Transplanted Lungs?
We report a successful case of living-donor lobar lung transplantation (LDLLT) for therapy-resistant broncho-bronchiolitis obliterans (BBO) after allogeneic hematopoietic stem cell transplantation (HSCT). Bron...
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Article
Mycophenolate Mofetil Is Effective and Well Tolerated in the Treatment of Refractory Acute and Chronic Graft-versus-Host Disease
We enrolled 11 patients with refractory graft-versus-host disease (GVHD) in a prospective trial evaluating the efficacy of mycophenolate mofetil (MMF). Four (67%) of the 6 patients with acute GVHD and all 5 pa...
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Article
Small follicular lymphoma arising near the ampulla of vater
A 49-yr-old Japanese woman underwent upper gastrointestinal endoscopy because of nonspecific dyspepsia. Endoscopy revealed a flat elevated lesion about 15 mm in diameter adjacent to the duodenal papilla, the s...
