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Article
Open AccessAntiproliferative effects of D-allose associated with reduced cell division frequency in glioblastoma
Recent studies have shown that D-allose, a rare sugar, elicits antitumor effects on different types of solid cancers, such as hepatocellular carcinoma, non-small-cell lung cancer, and squamous cell carcinoma o...
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Article
Hydrogen-Induced Delayed Fracture in a 1.5 GPa Dual-Phase Steel via Coalescence of Surface and Sub-surface Cracks
Hydrogen embrittlement susceptibility of a 1.5 GPa class ferrite/martensite dual-phase steel was evaluated using the U-bend test. Hydrogen-induced delayed fracture occurs via the coalescence of surface and sub-su...
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Article
Open AccessEffects of a monoclonal antibody against (pro)renin receptor on gliomagenesis
Glioblastoma is characterized by a strong self-renewal potential and poor differentiated state. We have reported previously that the (pro)renin receptor [(P)RR] is a potential target for glioma therapy by sile...
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Article
Open AccessNeuromorphic chip integrated with a large-scale integration circuit and amorphous-metal-oxide semiconductor thin-film synapse devices
Artificial intelligences are promising in future societies, and neural networks are typical technologies with the advantages such as self-organization, self-learning, parallel distributed computing, and fault ...
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Article
Open AccessAberrant (pro)renin receptor expression induces genomic instability in pancreatic ductal adenocarcinoma through upregulation of SMARCA5/SNF2H
(Pro)renin receptor [(P)RR] has a role in various diseases, such as cardiovascular and renal disorders and cancer. Aberrant (P)RR expression is prevalent in pancreatic ductal adenocarcinoma (PDAC) which is the...
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Article
Open Access(Pro)renin receptor promotes colorectal cancer through the Wnt/beta-catenin signalling pathway despite constitutive pathway component mutations
Although constitutive activating mutations in the Wnt/β-catenin signalling pathway are important for colorectal cancer development, canonical signalling through Wnt ligands is essential for β-catenin activatio...
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Article
Open Access(Pro)renin receptor is crucial for Wnt/β-catenin-dependent genesis of pancreatic ductal adenocarcinoma
Although Wnt/β-catenin signaling is known to be aberrantly activated in PDAC, mutations of CTNNB1, APC or other pathway components are rare in this tumor type, suggesting alternative mechanisms for Wnt/β-catenin ...
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Article
Life-history differentiation in Nymphoides coreana (Menyanthaceae) populations in aquatic habitats with different disturbance regimes in Japan
Different disturbance regimes in aquatic habitats may bring about life-history differentiation in aquatic plants. However, there is little information on this association. Adult longevity, seed size and mass, ...
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Article
Conservation of the Lake Kasumigaura population of Nymphoides indica (L.) Kuntze based on genetic evaluation using microsatellite markers
We compared the genetic diversity of the Lake Kasumigaura population of Nymphoides indica with that of pond populations in Hyogo and Kagawa Prefectures, which are thought to maintain high genetic diversity, to el...
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Article
Floral morph composition and pollen limitation in the seed set of Nymphoides indica populations
We investigated the floral morph composition and seed set of the populations in a heterostylous aquatic plant, Nymphoides indica O. Kuntze (Menyanthaceae). The bias of floral morph ratio in the populations was ne...
