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150 Result(s)
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Article
Open AccessNational survey on the current status of airway management in China
Apparently, understanding airway management status may help to reduce risk and improve clinical practice. Given these facts, our team conducted a second survey on the current status of airway management for ma...
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Article
Open AccessEngineered cytosine base editor enabling broad-scope and high-fidelity gene editing in Streptomyces
Base editing (BE) faces protospacer adjacent motif (PAM) constraints and off-target effects in both eukaryotes and prokaryotes. For Streptomyces, renowned as one of the most prolific bacterial producers of antibi...
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Article
Open AccessExploration on OCT biomarker candidate related to macular edema caused by diabetic retinopathy and retinal vein occlusion in SD-OCT images
To improve the understanding of potential pathological mechanisms of macular edema (ME), we try to discover biomarker candidates related to ME caused by diabetic retinopathy (DR) and retinal vein occlusion (RV...
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Open AccessPreparation of a self-matting, anti-fingerprint and skin-tactile wood coating via biomimetic self-wrinkling patterns
Inspired by natural wrinkled surfaces, artificial surfaces with biomimetic wrinkled structures have been widely used to improve optical properties, wettability, and antibacterial properties. However, the prepa...
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Article
Open AccessStructural insights into the DNA topoisomerase II of the African swine fever virus
Type II topoisomerases are ubiquitous enzymes that play a pivotal role in modulating the topological configuration of double-stranded DNA. These topoisomerases are required for DNA metabolism and have been ext...
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Open AccessWideband low-RCS and gain-enhanced antenna using frequency selective absorber based on patterned graphene
In this paper, a double-layer patterned graphene-based frequency-selective absorber (DGFSA) is proposed as a means of reducing an antenna’s radar cross-section (RCS) while simultaneously increasing its gain. T...
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Open AccessProteomic analysis of DEN and CCl4-induced hepatocellular carcinoma mouse model
Hepatocellular carcinoma (HCC) seriously threatens human health, mostly developed from liver fibrosis or cirrhosis. Since diethylnitrosamine (DEN) and carbon tetrachloride (CCl4)-induced HCC mouse model almost re...
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Article
Designing Membrane Electrode Assembly for Electrochemical CO2 Reduction: a Review
Currently, the electrochemical CO2 reduction reaction (CO2RR) can realize the resource conversion of CO2, which is a promising approach to carbon resource use. Important advancements have been made in exploring t...
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Article
Open AccessA haplotype-resolved genome provides insight into allele-specific expression in wild walnut (Juglans regia L.)
Wild germplasm resources are crucial for gene mining and molecular breeding because of their special trait performance. Haplotype-resolved genome is an ideal solution for fully understanding the biology of sub...
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Article
Open AccessWhat factors will affect the effectiveness of using ChatGPT to solve programming problems? A quasi-experimental study
The emergence of ChatGPT has sparked new expectations for AI-empowered educational transformation. However, it remains unknown which factors affect its effectiveness in empowering learners to solve programming...
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Open AccessEducation reform and change driven by digital technology: a bibliometric study from a global perspective
Amidst the global digital transformation of educational institutions, digital technology has emerged as a significant area of interest among scholars. Such technologies have played an instrumental role in enha...
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Article
Open AccessGlucocorticoids increase adiposity by stimulating Krüppel-like factor 9 expression in macrophages
The mechanisms underlying glucocorticoid (GC)-induced obesity are poorly understood. Macrophages are the primary targets by which GCs exert pharmacological effects and perform critical functions in adipose tis...
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Article
Open AccessApoL6 associates with lipid droplets and disrupts Perilipin1-HSL interaction to inhibit lipolysis
Adipose tissue stores triacylglycerol (TAG) in lipid droplets (LD) and release fatty acids upon lipolysis during energy shortage. We identify ApoL6 as a LD-associated protein mainly found in adipose tissue, sp...
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Open AccessStructural variants involved in high-altitude adaptation detected using single-molecule long-read sequencing
Structural variants (SVs), accounting for a larger fraction of the genome than SNPs/InDels, are an important pool of genetic variation, enabling environmental adaptations. Here, we perform long-read sequencing...
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Open AccessSingle cell multi-omics reveal intra-cell-line heterogeneity across human cancer cell lines
Human cancer cell lines have long served as tools for cancer research and drug discovery, but the presence and the source of intra-cell-line heterogeneity remain elusive. Here, we perform single-cell RNA-seque...
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Open AccessFour-dimensional hydrogel dressing adaptable to the urethral microenvironment for scarless urethral reconstruction
The harsh urethral microenvironment (UME) after trauma severely hinders the current hydrogel-based urethral repair. In fact, four-dimensional (4D) consideration to mimic time-dependent physiological processes ...
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Article
Open AccessA primate nigrostriatal atlas of neuronal vulnerability and resilience in a model of Parkinson’s disease
The degenerative process in Parkinson’s disease (PD) causes a progressive loss of dopaminergic neurons (DaNs) in the nigrostriatal system. Resolving the differences in neuronal susceptibility warrants an amena...
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Open AccessAn S-band multimode reflector antenna for a satellite constellation tracking system
A multimode reflector antenna is a new concept proposed by our team in recent years, which does not correspond to the use of the traditional multimode feed but to innovation in the reflector design. This paper...
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Article
Open AccessMulti-object detection for crowded road scene based on ML-AFP of YOLOv5
Aiming at the problem of multi-object detection such as target occlusion and tiny targets in road scenes, this paper proposes an improved YOLOv5 multi-object detection model based on ML-AFP (multi-level aggreg...
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Open AccessVersatile bubble maneuvering on photopyroelectric slippery surfaces
Contactless bubble manipulation with a high spatiotemporal resolution brings a qualitative leap forward in a variety of applications. Despite considerable advances, light-induced bubble maneuvering remains cha...