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Article
Open AccessExosome-transported circ_0061407 and circ_0008103 play a tumour-repressive role and show diagnostic value in non-small-cell lung cancer
Circular RNAs (circRNAs), one of the major contents of exosomes, have been shown to participate in the occurrence and progression of cancers. The role and the diagnostic potential of exosome-transported circRN...
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Article
Open AccessLncRNA AL139294.1 can be transported by extracellular vesicles to promote the oncogenic behaviour of recipient cells through activation of the Wnt and NF-κB2 pathways in non-small-cell lung cancer
Extracellular vesicles (EVs) participate in cancer development via cell-to-cell communication. Long non-coding RNAs (lncRNAs), one component of EVs, can play an essential role in non-small-cell lung cancer (NS...
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Article
Short-axis PET image quality improvement based on a uEXPLORER total-body PET system through deep learning
The axial field of view (AFOV) of a positron emission tomography (PET) scanner greatly affects the quality of PET images. Although a total-body PET scanner (uEXPLORER) with a large AFOV is more sensitive, it i...
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Article
Open AccessCombined assisted bone age assessment and adult height prediction methods in Chinese girls with early puberty: analysis of three artificial intelligence systems
The applicability and accuracy of artificial intelligence (AI)-assisted bone age assessment and adult height prediction methods in girls with early puberty are unknown.
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Article
Open AccessSecondary oxidized di-2-ethylhexyl phthalate metabolites may be associated with progression from isolated premature thelarche to central precocious or early puberty
Phthalate esters (PAEs) may act as estrogen receptor agonists, and their relationship with precocious puberty is a global health concern. However, their role in isolated premature thelarche (IPT) progression r...
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Article
c-FLIP promotes drug resistance in non-small-cell lung cancer cells via upregulating FoxM1 expression
The forkhead box M1 (FoxM1) protein, a transcription factor, plays critical roles in regulating tumor growth and drug resistance, while cellular FLICE-inhibitory protein (c-FLIP), an anti-apoptotic regulator, ...
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Article
Regenerative Braking Control Strategy Based on Multi-source Information Fusion under Environment Perception
In this paper, regenerative braking control of electric vehicles is investigated based on multi-source information such as image recognition, GPS and vehicle running parameters. Firstly, the fast normalized cr...
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Chapter and Conference Paper
Comparison of Anthropometrics Between Boys and Girls in Desks and Chairs
This experiment compares the human body data measured by boys and girls in middle school students, aiming to verify whether the design of the desk and chair size is applicable to both boys and girls of the sam...
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Chapter and Conference Paper
T-Bert: A Spam Review Detection Model Combining Group Intelligence and Personalized Sentiment Information
The content of online comments largely affects users’ willingness to purchase goods or services. Driven by interests, spam reviews continue to emerge to induce users maliciously. Most of the existing related w...
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Article
Management of Gout-associated MSU crystals-induced NLRP3 inflammasome activation by procyanidin B2: targeting IL-1β and Cathepsin B in macrophages
Gout, the most prevalent inflammatory arthritis worldwide, released interleukin-1β (IL-1β) and Cathepsin B inflammatory mediators that constitute the hallmark of the disease. Herein we aimed to investigate whe...
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Article
Magnolol inhibits myotube atrophy induced by cancer cachexia through myostatin signaling pathway in vitro
Cancer cachexia is a complex and multifactorial syndrome that influences about 50–80% of cancer patients and may lead to 20% of cancer deaths and muscle atrophy is the key characteristic of the syndrome. Recen...
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Article
Open AccessPim1 kinase positively regulates myoblast behaviors and skeletal muscle regeneration
Adult skeletal muscle regeneration after injury depends on normal myoblast function. However, the intrinsic mechanisms for the control of myoblast behaviors are not well defined. Herein, we identified Pim1 kin...
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Article
Honokiol inhibits breast cancer cell metastasis by blocking EMT through modulation of Snail/Slug protein translation
Honokiol (HNK), an active compound isolated from traditional Chinese medicine Magnolia officinalis, has shown potent anticancer activities. In the present study, we investigated the effects of HNK on breast cance...
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Article
Open AccessIMB0901 inhibits muscle atrophy induced by cancer cachexia through MSTN signaling pathway
Cancer cachexia as a metabolic syndrome can lead to at least 25% of cancer deaths. The inhibition of muscle atrophy is a main strategy to treat cancer cachexia. In this process, myostatin (MSTN) can exert a du...
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Article
High-fat diet consumption reduces hepatic folate transporter expression via nuclear respiratory factor-1
Folate is an essential micronutrient for biological function. The liver, a primary organ for folate metabolism and storage, plays an important role in folate homeostasis. Proton-coupled folate transporter (PCF...
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Article
Open AccessAzithromycin enhances anticancer activity of TRAIL by inhibiting autophagy and up-regulating the protein levels of DR4/5 in colon cancer cells in vitro and in vivo
Azithromycin is a member of macrolide antibiotics, and has been reported to inhibit the proliferation of cancer cells. However, the underlying mechanisms are not been fully elucidated. Tumor necrosis factor-re...
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Article
Open AccessKnockout of zebrafish interleukin 7 receptor (IL7R) by the CRISPR/Cas9 system delays retinal neurodevelopment
Interleukin 7 receptor (il7r), a transmembrane receptor, belongs to the type I cytokine receptor family. Il7r is involved in the pathogenesis of neurodegenerative disorders, such as multiple sclerosis. Targeted k...
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Article
Short Term High Fat Diet Induces Obesity-Enhancing Changes in Mouse Gut Microbiota That are Partially Reversed by Cessation of the High Fat Diet
The gut microbiota is proposed as a “metabolic organ” involved in energy utilization and is associated with obesity. Dietary intervention is one of the approaches for obesity management. Changes in dietary com...
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Article
RGD and NGR modified TRAIL protein exhibited potent anti-metastasis effects on TRAIL-insensitive cancer cells in vitro and in vivo
The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has been considered to be a promising anti-tumor agent since the discovery of TRAIL-mediated apoptosis specifically on cancer cells. However,...
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Chapter and Conference Paper
ProbitUCB: A Novel Method for Review Ranking
Online reviews play an important role in facilitating customers in making online purchase decisions. But with the dramatic increase in volume, it will cost customers hours going through all the reviews. This p...
