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Article
Mitogen-Activated Protein Kinases Mediate Adventitial Fibroblast Activation and Neointima Formation via GATA4/Cyclin D1 Axis
Activation of mitogen-activated protein kinases (MAPKs) by pathological stimuli participates in cardiovascular diseases. Dysfunction of adventitial fibroblast has emerged as a critical regulator in vascular re...
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Article
Open AccessA dynamic visualization clinical tool constructed and validated based on the SEER database for screening the optimal surgical candidates for bone metastasis in primary kidney cancer
The implementation of primary tumor resection (PTR) in the treatment of kidney cancer patients (KC) with bone metastases (BM) has been controversial. This study aims to construct the first tool that can accura...
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Article
The predictive value of advanced lung cancer inflammation index for short-term outcomes and prognosis of colorectal cancer patients who underwent radical surgery
The purpose of this study was to investigate the predictive value of advanced lung cancer inflammation index (ALI) for short-term outcomes and prognosis of colorectal cancer (CRC) patients who underwent radica...
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Article
A comparative study on laparoscopic and open surgical approaches for perforated peptic ulcer repair: efficacy and outcomes analysis
This study aimed to compare the clinical outcomes of the clinical outcomes of laparoscopic and open sutures for peptic ulcer perforation (PPU).
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Article
Open AccessHyperuricemia remission after colorectal cancer surgery for colorectal cancer patients
The purpose of this study was to investigate whether patients with colorectal cancer (CRC) combined with hyperuricemia remitted 1 year after CRC surgery. CRC patients combined with hyperuricemia who underwent ...
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Article
Open AccessTotal intravenous anesthesia for geriatric hip fracture with severe systemic disease
Our study aimed to determine the impact of a novel technique of anesthesia administration on the clinical outcomes and complications in geriatric patients with severe systemic disease undergoing hip surgery.
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Article
Web-based nomogram and risk stratification system constructed for predicting the overall survival of older adults with primary kidney cancer after surgical resection
Kidney cancer (KC) is one of the most common malignant tumors in adults which particularly affects the survival of elderly patients. We aimed to construct a nomogram to predict overall survival (OS) in elderly...
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Article
Two novel clinical tools to predict the risk of bone metastasis and overall survival in esophageal cancer patients: a large population-based retrospective cohort study
The aim of this study was to construct two web-based nomograms to predict the probability of bone metastasis (BM) in esophageal cancer (EC) patients and the prognostic of EC patients with BM (ECBM).
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Article
Understanding Mass Dependence of Glass Formation in Ring Polymers
Having highly tunable molecular topology is one of the most important characteristics of polymers that provides these materials with a wide range of interesting and unique properties. In particular, ring polym...
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Article
Two potentially distinct pathways to geographic atrophy in age-related macular degeneration characterized by quantitative fundus autofluorescence
To demonstrate two distinct pathways to geographic atrophy (GA) that originate from soft drusen/ pigment epithelial detachments (PEDs) and subretinal drusenoid deposits (SDDs), respectively, and are characteri...
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Article
Recent Progress of Conductive Metal–Organic Frameworks for Electrochemical Energy Storage
The development of reliable and low-cost energy storage systems is of considerable value in using renewable and clean energy sources, and exploring advanced electrodes with high reversible capacity, excellent ...
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Article
Mathematical representation of 2D image boundary contour using fractional implicit polynomial
Implicit polynomial (IP) fitting is an effective method to quickly represent two-dimensional (2D) image boundary contour in the form of mathematical function. Under the same maximum degree, the fractional impl...
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Article
Do colorectal cancer patients with a postoperative stoma have sexual problems? A pooling up analysis of 2566 patients
This study aimed to evaluate the effect of the stoma on sexual function in colorectal cancer patients.
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Article
Fitting objects with implicit polynomials by deep neural network
Implicit polynomials (IPs) are considered as a powerful tool for object curve fitting tasks due to their simplicity and fewer parameters. The traditional linear methods, such as 3L, MinVar, and MinMax, often a...
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Article
Structures of the ADGRG2–Gs complex in apo and ligand-bound forms
Adhesion G protein-coupled receptors are elusive in terms of their structural information and ligands. Here, we solved the cryogenic-electron microscopy (cryo-EM) structure of apo-ADGRG2, an essential membrane...
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Article
Open AccessPhosphorylation of Jhd2 by the Ras-cAMP-PKA(Tpk2) pathway regulates histone modifications and autophagy
Cells need to coordinate gene expression with their metabolic states to maintain cell homeostasis and growth. How cells transduce nutrient availability to appropriate gene expression remains poorly understood....
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Article
Open AccessElectrocatalytic Oxygen Reduction to Produce Hydrogen Peroxide: Rational Design from Single-Atom Catalysts to Devices
Electrocatalytic production of hydrogen peroxide (H2O2) via the 2e− transfer route of the oxygen reduction reaction (ORR) offers a promising alternative to the energy-intensive anthraquinone process, which domina...
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Article
Photocatalytic TiO2/PDMS coating to drive self-cleaning: a facile approach for anti-stain silicone rubber surfaces
The formation of a robust photocatalytic hydrophobic hybrid coating on a polymer substrate via a simple process, such as dip-coating, is useful for practical applications but still challenging. In this study, ...
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Article
A systematic review and meta-analysis on prevalence of and risk factors associated with depression, anxiety and insomnia in infectious diseases, including COVID-19: a call to action
Infectious disease epidemics have become more frequent and more complex during the 21st century, posing a health threat to the general public and leading to psychological symptoms. The current study was designed ...
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Article
MeshCNN-based BREP to CSG conversion algorithm for 3D CAD models and its application
In the field of neutronics analysis, it is imperative to develop computer-aided modeling technology for Monte Carlo codes to address the increasing complexity of reactor core components by converting 3D CAD mo...
