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    Article

    EGFR activation limits the response of liver cancer to lenvatinib

    Hepatocellular carcinoma (HCC)—the most common form of liver cancer—is an aggressive malignancy with few effective treatment options1. Lenvatinib is a small-molecule inhibitor of multiple receptor tyrosine kinase...

    Haojie **, Yao** Shi, Yuanyuan Lv, Shengxian Yuan, Christel F. A. Ramirez in Nature (2021)

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    Open Access

    circNDUFB2 inhibits non-small cell lung cancer progression via destabilizing IGF2BPs and activating anti-tumor immunity

    Circular RNAs (circRNA) are a class of covalently closed single-stranded RNAs that have been implicated in cancer progression. Here we identify circNDUFB2 to be downregulated in non-small cell lung cancer (NSCLC)...

    Botai Li, Lili Zhu, Chunlai Lu, Cun Wang, Hui Wang, Haojie ** in Nature Communications (2021)

  3. Article

    Open Access

    circTP63 functions as a ceRNA to promote lung squamous cell carcinoma progression by upregulating FOXM1

    Circular RNAs (circRNAs) are identified as vital regulators in a variety of cancers. However, the role of circRNA in lung squamous cell carcinoma (LUSC) remains largely unknown. Herein, we explore the expressi...

    Zhuoan Cheng, Chengtao Yu, Shaohua Cui, Hui Wang, Haojie ** in Nature Communications (2019)

  4. Article

    Open Access

    TRIM14 regulates cell proliferation and invasion in osteosarcoma via promotion of the AKT signaling pathway

    Recent studies have shown that some members of the tripartite motif-containing protein (TRIM) family serve as important regulators of tumorigenesis. However, the biological role of TRIM14 in osteosarcoma remai...

    Guoxing Xu, Yongfei Guo, Dabo Xu, Yi Wang, Yafeng Shen, Feifei Wang in Scientific Reports (2017)