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Article
Cryo-EM structure of human sphingomyelin synthase and its mechanistic implications for sphingomyelin synthesis
Sphingomyelin (SM) has key roles in modulating mammalian membrane properties and serves as an important pool for bioactive molecules. SM biosynthesis is mediated by the sphingomyelin synthase (SMS) family, com...
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Article
Open AccessQa-SNARE syntaxin 18 mediates lipid droplet fusion with SNAP23 and SEC22B
Lipid droplets (LDs) are dynamic lipid storage organelles that can sense and respond to changes in systemic energy balance. The size and number of LDs are controlled by complex and delicate mechanisms, among w...
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Article
Open AccessThe structural pathology for hypophosphatasia caused by malfunctional tissue non-specific alkaline phosphatase
Hypophosphatasia (HPP) is a metabolic bone disease that manifests as developmental abnormalities in bone and dental tissues. HPP patients exhibit hypo-mineralization and osteopenia due to the deficiency or mal...
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Article
Open AccessThe structural basis of the pH-homeostasis mediated by the Cl−/HCO3− exchanger, AE2
The cell maintains its intracellular pH in a narrow physiological range and disrupting the pH-homeostasis could cause dysfunctional metabolic states. Anion exchanger 2 (AE2) works at high cellular pH to cataly...
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Article
Open AccessThe structural basis for the phospholipid remodeling by lysophosphatidylcholine acyltransferase 3
As the major component of cell membranes, phosphatidylcholine (PC) is synthesized de novo in the Kennedy pathway and then undergoes extensive deacylation-reacylation remodeling via Lands’ cycle. The re-acylati...
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Article
Open AccessCAR exosomes derived from effector CAR-T cells have potent antitumour effects and low toxicity
Genetically engineered T cells expressing a chimeric antigen receptor (CAR) are rapidly emerging a promising new treatment for haematological and non-haematological malignancies. CAR-T therapy can induce rapid...
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Article
Open AccessTRIM14 regulates cell proliferation and invasion in osteosarcoma via promotion of the AKT signaling pathway
Recent studies have shown that some members of the tripartite motif-containing protein (TRIM) family serve as important regulators of tumorigenesis. However, the biological role of TRIM14 in osteosarcoma remai...
