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Article
Modeling Hydrogen Spillover on Oxide Catalytic Centers
The spillover of hydrogen on an inorganic oxide support is studied using DFT calculations. Quantum-chemical calculations for model catalytic sites with structure H(–Al–O–)3(OH)6 and HH+(‒Al–O–)3(OH)6 are performe...
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Article
Solid-State Catalytic Hydrogen/Deuterium Exchange in Mexidol
The reaction between spillover hydrogen (SH) and mexidol upon high-temperature solid state catalytic isotope exchange (HSCIE) is studied experimentally and via DFT B3LYP and MP2 calculations. The distribution ...
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Article
Influence of Subchronic Administration of the HLDF-6 Peptide on an Efficacy of the Exploratory Behavior of Inbred Mice of the Balb/c and C57Bl/6 Strains
A comparative analysis of the psychotropic activity of the HDLF-6 peptide in the acidic form (TGENHR) and the amide form (HLDF-6-amide, TGENHR-NH2) was carried out using the method for the behavioral assessing of...
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Article
Investigation of the Hydrolytic Stability of the HLDF-6-AA Antitumor Peptide by the Method of Accelerated Aging
The HLDF-6 hexapeptide corresponded to the 41–46 (TGENHR) fragment of the Human Leukemia Differentiation Factor (HLDF) and exhibited a wide spectrum of neuroprotective, normalizing, anxiolytic, nootropic, and ...
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Article
Pharmacokinetics of HLDF-6-AA Peptide in the Organism of Experimental Animals
Pharmacokinetics of the promising antitumor peptide HLDF-6-AA (Ac-ThrGlyGluAsnHisArg-NH2) was studied using its uniformly tritiated derivative. Experiments were performed on male Wistar rats, Balb/c mice and Chin...
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Article
Proteolytic Hydrolysis of the Antitumor Peptide HLDF-6-AA in Blood Plasma
HLDF-6 hexapeptide, which corresponds to the 41TGENHR46 fragment of human leukemia differentiation factor (HLDF), shows a wide range of neuroprotective, normalizing, anxiolytic, nootropic and antitumor activities...
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Article
Solid-State Catalytic Isotope Exchange of Hydrogen for Deuterium in Cyclopropylglycine
The reaction of spillover hydrogen (SH) with cyclopropylglycine (cPG) in high-temperature solid-state catalytic hydrogen isotope exchange (HTCIE) has been studied experimentally and using density functional th...
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Article
Studying the Toxic Effects of Some Biologically Active Peptides on the Model of Mouse Embryonic Stem Cells
We studied the effects of peptide drugs (HLDF-6, PGP, RPGP, and PGLP) and peptide pharmaceutical products (Semax, Selank, and thyroliberin) on proliferation and survival of mouse embryonic stem cells and their...
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Article
The qualitative analysis of the amide of the HLDF-6 peptide and its metabolites in tissues of laboratory animals with the use of tritium-labeled and deuterium-labeled derivatives
The novel method for the peptide pharmacokinetics in tissues of laboratory animals was elaborated by the example of the HLDF-6 peptide amide. This method practically completely prevented the proteolytic degrad...
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Article
Neurotensin-Like Peptides as Potential Antipsychotics: Modulation of the Serotonin System
Neurotensin-like peptides acting as functional antagonists of serotonin receptors were revealed in the head-shaking test on mice. The neurotensin-like peptides block the serotonin-induced platelet aggregation ...
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Article
Solid phase isotope exchange of deuterium and tritium for hydrogen in human recombinant insulin
Reaction of a high-temperature solid-phase catalytic isotope exchange in peptides and proteins under the action of the catalytically activated spillover hydrogen was studied. The reaction of human recombinant ...
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Article
The effects of nootropic drugs on metabotropic glutamate receptors in the brains of BALB/c and C57BL/6 mice
We studied the effects of subchronic administration of various nootropic drugs, such as piracetam, phenotropil, noopept, semax, pantogam, and nooglutil on the neurochemical characteristics of metabotropic glut...
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Article
Interaction of synthetic peptide octarphin with human blood lymphocytes
The synthetic peptide octarphin (TPLVTLFK, fragment 12–19 of β-endorphin), a selective agonist of nonopioid β-endorphin receptor, was prepared with specific activity 28 Ci/mmol. The binding of [3H]octarphin to T ...
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Article
Blood-brain barrier unlocked
The brain is protected by a physiological blood-brain barrier (BBB) against toxins and some metabolites circulating in the blood. At the same time, the BBB limits penetration into the brain of many neuroactive...
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Article
Immunostimulating effect of the synthetic peptide octarphin corresponding to β-endorphin fragment 12–19
We have synthesized the peptide TPLVTLFK corresponding to β-endorphin fragment 12–19 (dubbed octarphin) and its analogs (LPLVTLFK, TLLVTLFK, TPLVLLFK, TPLVTLLK, TPLVTLFL). The octarphin peptide was labeled wit...
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Article
Properties and mechanism of the action of the synthetic peptide octarphin
The peptide TPLVTLFK, whose amino acid sequence corresponds to the 12–19 fragment of β-endorphin (the author’s name for the peptide octarphin), and its analogues (LPLVTLFK, TLLVTLFK, TPLVLLFK, TPLVTLLK, and TP...
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Article
Stress-protective activity of the CH3CO-Lys-Lys-Arg-Arg-NH2 synthetic peptide (protectin)
The CH3CO-Lys-Lys-Arg-Arg-NH2 peptide (the author has named it protectin) was synthesized, and its activity was studied during different stress actions. Protectin was found to normalize the content of corticoster...
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Article
Ligands of glutamate and dopamine receptors evenly labeled with hydrogen isotopes
A reaction of high-temperature solid-phase catalytic isotope exchange (HSCIE) was studied for the preparation of tritium- and deuterium-labeled ligands of glutamate and dopamine receptors. Tritium-labeled (5S,10R
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Article
Solid phase reaction of hemoglobin with spillover hydrogen
The reaction of high-temperature solid-state catalytic isotope exchange (HSCIE) between bovine hemoglobin and spillover hydrogen (SH) was studied. It was shown that, in the field of subunit contact, there is a...
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Article
Stress-protective effect of the KKRR synthetic peptide corresponding to the 15–18 sequence of human adrenocorticotropic hormone
The activity of the KKRR synthetic peptide corresponding to the 15-18 sequence of human adrenocorticotropic hormone (ACTH) and its analogues: KKKK, RRRR, RRKK, kKRR, KkRR, KKrR, and KKRr (amino acid residues o...
