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  1. Article

    Open Access

    Hardwiring tissue-specific AAV transduction in mice through engineered receptor expression

    The development of transgenic mouse models that express genes of interest in specific cell types has transformed our understanding of basic biology and disease. However, generating these models is time- and re...

    James Zengel, Yu **n Wang, Jai Woong Seo, Ke Ning, James N. Hamilton in Nature Methods (2023)

  2. No Access

    Article

    Cytochalasans and azaphilones: suitable chemotaxonomic markers for the Chaetomium species

    The accurate taxonomic concept of the fungal Chaetomium species has been a hard work due to morphological similarity. Chemotaxonomy based on secondary metabolites is a powerful tool for taxonomical purposes, whic...

    Meng-Yue Yang, Yu-**n Wang, Qing-Hua Chang in Applied Microbiology and Biotechnology (2021)

  3. No Access

    Protocol

    Single EDL Myofiber Isolation for Analyses of Quiescent and Activated Muscle Stem Cells

    Adult satellite cells are quiescent, but are poised for activation in response to exercise, injury, or disease allowing adult muscle growth or repair. Once activated, satellite cells proliferate extensively to...

    Caroline E. Brun, Yu **n Wang, Michael A. Rudnicki in Cellular Quiescence (2018)

  4. No Access

    Protocol

    Primary Mouse Myoblast Purification using Magnetic Cell Separation

    Primary myoblasts can be isolated from mouse muscle cell extracts and cultured in vitro. Muscle cells are usually dissociated manually by mincing with razor blades or scissors in a collagenase/dispase solution...

    Marie Claude Sincennes, Yu **n Wang, Michael A. Rudnicki in Muscle Stem Cells (2017)

  5. No Access

    Article

    Safety and Effectiveness of Intravenous Thrombolysis with Recombinant Tissue Plasminogen Activator in 80 Years and Older Acute Ischemic Stroke Patients

    This study aims to explore the safety and efficacy of intravenous thrombolysis (IVT) with recombinant tissue plasminogen activator (rt-PA) in elderly (≥80 years old) acute ischemic stroke (AIS) patients. The c...

    Yan Chen, Chen-hua Li, Yu-**n Wang, Chen-Hao Zhang in Cell Biochemistry and Biophysics (2015)

  6. No Access

    Article

    Efficacy and Safety of Intravenous Thrombolysis for the Treatment of Acute Ischemic Stroke Patients with Saccular Intracranial Aneurysms of ≤3 mm

    To explore the effectiveness and safety of intravenous thrombolysis (IVT) using recombinant tissue plasminogen activator in treating acute ischemic stroke patients with concomitant intracranial aneurysms (IA)...

    Chen-Hao Zhang, Chenhua Li, Yu-**n Wang, Yan Chen in Cell Biochemistry and Biophysics (2015)

  7. No Access

    Article

    Use of Intravenous Thrombolytic Therapy in Acute Ischemic Stroke Patients: Evaluation of Clinical Outcomes

    The use of intravenous thrombolytic therapy (ITT) in acute ischemic stroke (AIS) patients is still debated in China. We present the analysis of clinico-demographic retrospective data of 646 AIS patients that w...

    Pei-Lan Zhang, Yu-**n Wang, Yan Chen, Chen-Hao Zhang in Cell Biochemistry and Biophysics (2015)

  8. No Access

    Article

    VEGF +936C/T and +460C/T gene polymorphisms and oral cancer risk: a meta-analysis

    Many studies have examined the association between the VEGF +936C/T (rs833061) and +460C/T (rs3025039) gene polymorphisms and oral cancer risk in various populations, but their results have been inconsistent. To ...

    Su-Feng Zhao, ** Zhan, Xu-Dong Yang, Ming-**ng Lu in Molecular Biology Reports (2013)

  9. No Access

    Article

    Satellite cells, the engines of muscle repair

    Satellite cells are a heterogeneous population of stem and progenitor cells with crucial roles in muscle repair and regeneration. Although paired-box 7 (PAX7) is necessary to maintain the undifferentiated stem...

    Yu **n Wang, Michael A. Rudnicki in Nature Reviews Molecular Cell Biology (2012)