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  1. No Access

    Article

    The Critical Role of Equilibrative Nucleoside Transporter-2 in Modulating Cerebral Damage and Vascular Dysfunction in Mice with Brain Ischemia-Reperfusion

    Cerebral vascular protection is critical for stroke treatment. Adenosine modulates vascular flow and exhibits neuroprotective effects, in which brain extracellular concentration of adenosine is dramatically in...

    Hui-Ling Chiang, Kuo-Chen Wu, You-Yin Chen, Chin-Jui Ho… in Pharmaceutical Research (2023)

  2. No Access

    Article

    Gossypol, a novel modulator of VCP, induces autophagic degradation of mutant huntingtin by promoting the formation of VCP/p97-LC3-mHTT complex

    Huntington’s disease (HD) is an autosomal dominant neurodegenerative disorder caused by toxic aggregates of mutant huntingtin protein (mHTT) in the brain. Decreasing mHTT is a potential strategy for therapeuti...

    **ao-**g Li, Yuan-yuan Zhang, Yu-hua Fu, Hao Zhang… in Acta Pharmacologica Sinica (2021)