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    Article

    Screening gene signatures for clinical response subtypes of lung transplantation

    Lung is the most important organ in the human respiratory system, whose normal functions are quite essential for human beings. Under certain pathological conditions, the normal lung functions could no longer b...

    Yu-Hang Zhang, Zhan Dong Li, Tao Zeng, Lei Chen in Molecular Genetics and Genomics (2022)

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    Predicting gene phenotype by multi-label multi-class model based on essential functional features

    Phenotype is one of the most significant concepts in genetics, which is used to describe all the characteristics of a research object that can be observed. Considering that phenotype reflects the integrated fe...

    Lei Chen, Zhandong Li, Tao Zeng, Yu-Hang Zhang, Hao Li in Molecular Genetics and Genomics (2021)

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    Identification of the copy number variant biomarkers for breast cancer subtypes

    Breast cancer is a common and threatening malignant disease with multiple biological and clinical subtypes. It can be categorized into subtypes of luminal A, luminal B, Her2 positive, and basal-like. Copy numb...

    **aoyong Pan, **aoHua Hu, Yu-Hang Zhang, Lei Chen in Molecular Genetics and Genomics (2019)

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    Discriminating cirRNAs from other lncRNAs using a hierarchical extreme learning machine (H-ELM) algorithm with feature selection

    As non-coding RNAs, circular RNAs (cirRNAs) and long non-coding RNAs (lncRNAs) have attracted an increasing amount of attention. They have been confirmed to participate in many biological processes, including ...

    Lei Chen, Yu-Hang Zhang, Guohua Huang, **aoyong Pan in Molecular Genetics and Genomics (2018)

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    Identification of compound–protein interactions through the analysis of gene ontology, KEGG enrichment for proteins and molecular fragments of compounds

    Compound–protein interactions play important roles in every cell via the recognition and regulation of specific functional proteins. The correct identification of compound–protein interactions can lead to a go...

    Lei Chen, Yu-Hang Zhang, Mingyue Zheng, Tao Huang in Molecular Genetics and Genomics (2016)

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    Identifying novel protein phenotype annotations by hybridizing protein–protein interactions and protein sequence similarities

    Studies of protein phenotypes represent a central challenge of modern genetics in the post-genome era because effective and accurate investigation of protein phenotypes is one of the most critical procedures t...

    Lei Chen, Yu-Hang Zhang, Tao Huang, Yu-Dong Cai in Molecular Genetics and Genomics (2016)