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Article
Open AccessCD276 enhances sunitinib resistance in clear cell renal cell carcinoma by promoting DNA damage repair and activation of FAK-MAPK signaling pathway
This study aimed to explore the effect of CD276 expression on the sunitinib sensitivity of clear cell renal cell carcinoma (ccRCC) cell and animal models and the potential mechanisms involved.
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Article
Open AccessEffects of soft robotic exosuit on ambulation ability in stroke patients: a systematic review
Robot-assisted gait training is incorporated into guidelines for stroke rehabilitation. It is a promising tool combined with conventional therapy for low ambulatory patients. The heavy weight and bulky appeara...
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Article
BL-918, a small-molecule activator of ULK1, induces cytoprotective autophagy for amyotrophic lateral sclerosis therapy
Amyotrophic lateral sclerosis (ALS) is one of the most common fatal neurodegenerative diseases in adults. ALS pathogenesis is associated with toxic SOD1 aggregates generated by mutant SOD1. Since autophagy is ...
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Article
N-terminal propeptide of type 3 collagen-based sequential algorithm can identify high-risk steatohepatitis and fibrosis in MAFLD
With metabolic dysfunction-associated fatty liver disease (MAFLD) incidence and prevalence sharply increasing globally, there is an urgent need for non-invasive diagnostic tests to accurately screen high-risk ...
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Article
Sex-related differences in safety profiles, pharmacokinetics and tissue distribution of sinomenine hydrochloride in rats
Sinomenine is a bioactive alkaloid isolated from the Chinese medicinal plant Sinomenium acutum (Thunb.) Rehd. et Wils which exhibits significant analgesic, anti-inflammatory, and immunosuppressive effects. Sinome...
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Article
Patchouli alcohol as a selective estrogen receptor β agonist ameliorates AD-like pathology of APP/PS1 model mice
Clinical evidence shows that postmenpausal women are almost twice as likely to develop Alzheimer’s disease (AD) as men of the same age, and estrogen is closely related to the occurrence of AD. Estrogen recepto...
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Article
Open AccessExternal validation of a machine learning model to predict hemodynamic instability in intensive care unit
Early prediction model of hemodynamic instability has the potential to improve the critical care, whereas limited external validation on the generalizability. We aimed to independently validate the Hemodynamic...
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Article
Open AccessThe role of S100A9 in the interaction between pancreatic ductal adenocarcinoma cells and stromal cells
A major feature of the microenvironment in pancreatic ductal adenocarcinoma (PDAC) is the significant amount of extracellular matrix produced by pancreatic stellate cells (PSCs), which have been reported to en...
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Article
Evaluating the advantages of treating acute cholecystitis by following the Tokyo Guidelines 2018 (TG18): a study emphasizing clinical outcomes and medical expenditures
Acute cholecystitis (AC) is a common surgical emergency. The Tokyo Guidelines 2018 (TG18) provides a reliable algorithm for the treatment of AC patients to achieve optimal outcomes. However, the economic benef...
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Article
Open AccessIn vitro genome editing rescues parkinsonism phenotypes in induced pluripotent stem cells-derived dopaminergic neurons carrying LRRK2 p.G2019S mutation
The c.G6055A (p.G2019S) mutation in leucine-rich repeat kinase 2 (LRRK2) is the most prevalent genetic cause of Parkinson’s disease (PD). CRISPR/Cas9-mediated genome editing by homology-directed repair (HDR) has ...
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Article
Open AccessEighteen years’ experience of traumatic subclavian vascular injury in a tertiary referral trauma center
Traumatic subclavian vascular injury (TSVI) is rare but often fatal. The precise diagnosis of TSVI remains challenging mainly because of its occult nature, less typical presentations, and being overlooked in t...
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Article
Open AccessDeciphering the effect of citric acid on arsenic adsorption with phosphorene in aqueous solution
This paper presents the first attempt to explore the potential of phosphorene as an adsorbent for arsenic [AS(III) and As(V)] removal under competition adsorption with citric acid (CA). In this study, the phos...
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Article
Deep coma does not always predict poor outcomes among patients with polytrauma
This study aimed to clarify the prognosis of polytrauma patients presenting to the emergency department (ED) with a Glasgow Coma Scale score (GCS) of 3.
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Article
3-Acetyl-oleanolic acid ameliorates non-alcoholic fatty liver disease in high fat diet-treated rats by activating AMPK-related pathways
3-Acetyl-oleanolic acid (3Ac-OA) is a derivative of oleanolic acid (OA), which has shown therapeutic beneficial effects on diabetes and metabolic syndrome. In this study we investigated whether 3Ac-OA exerted ...
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Article
Open AccessPostoperative dental morbidity in children following dental treatment under general anesthesia
General anesthesia has been widely used in pediatric dentistry in recent years. However, there remain concerns about potential postoperative dental morbidity. The goal of this study was to identify the frequen...
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Article
Open AccessAnalysis for Patient Survival after Open Abdomen for Torso Trauma and the Impact of Achieving Primary Fascial Closure: A Single-Center Experience
Open abdomen indicates the abdominal fascia is unclosed to abbreviate surgery and to reduce physiological stress. However, complications and difficulties in patient care are often encountered after operation. ...
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Article
Carnosine suppresses oxygen-glucose deprivation/recovery-induced proliferation and migration of reactive astrocytes of rats in vitro
Glial scar formation resulted from excessive astrogliosis limits axonal regeneration and impairs recovery of function, thus an intervention to ameliorate excessive astrogliosis is crucial for the recovery of n...
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Article
Protecting single-photon entanglement with practical entanglement source
Single-photon entanglement (SPE) is important for quantum communication and quantum information processing. However, SPE is sensitive to photon loss. In this paper, we discuss a linear optical amplification pr...
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Article
Distillation of arbitrary single-photon entanglement assisted with polarized Bell states
Single-photon entanglement (SPE) is a promising resource in quantum communication. However, it will suffer from the photon loss. In this paper, we will present an efficient approach to protect the two-mode SPE...
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Article
Protecting single-photon entanglement with imperfect single-photon source
Photon noiseless linear amplification (NLA) is a powerful way to protect the single photon or single-photon entanglement (SPE) from photon loss. However, current NLA protocols for single photon or SPE usually ...
