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Open AccessPrognostic factors in 448 newly diagnosed multiple myeloma receiving bortezomib-based induction: impact of ASCT, transplant refusal and high-risk MM
In Hong Kong, newly diagnosed multiple myeloma (NDMM) receives bortezomib-based triplet induction. Upfront autologous stem cell transplant (ASCT) is offered to transplant eligible (TE) patients (NDMM ≤ 65 year...
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Article
Open AccessHepatitis B virus reactivation in seronegative occult hepatitis B patient receiving ibrutinib therapy
Ibrutinib is a Bruton’s tyrosine kinase (BTK) inhibitor approved for the treatment for several mature B-cell malignancies. Reactivation of hepatitis B virus (HBV) is a well-described complication in patients w...
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Article
Eltrombopag as frontline treatment of aplastic anaemia in routine practice: implications on cost and efficacy
The thrombopoietin mimetic eltrombopag (EPAG) is efficacious in clinical trials of newly diagnosed moderate (M), severe (S) and very severe (vS) aplastic anaemia (AA). Its use in routine practice and resource-...
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Article
Epstein-Barr virus–positive diffuse large B-cell lymphoma after frontline brentuximab vedotin treatment of classical Hodgkin lymphoma
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Ruxolitinib in the management of steroid-resistant/-dependent acute and chronic graft-versus-host disease: results of routine practice in an academic centre
Graft-versus-host disease (GVHD) is an important complication after allogeneic haematopoietic stem cell transplantation (HSCT). Corticosteroids are the standard first-line treatment. Steroid-resistant/-depende...
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Article
Spectrum of B-cell neoplasms associated with immunoglobulin G4-related disease
Immunoglobulin G4-related disease (IgG4-RD) has rarely been associated with lymphoid neoplasms, the spectrum of which remains unclear. B-cell lymphoid neoplasms (LN) associated with IgG4-RD diagnosed in a 4-ye...
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Thrombotic thrombocytopenic purpura as the presenting feature of human herpesvirus 6 myocarditis
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Endocrine complications in patients with transfusion-dependent thalassaemia after haemopoietic stem cell transplantation
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Complete response of age-related Epstein-Barr virus-associated polymorphic nodal lymphoproliferative disease of plasmacytic type to low-dose lenalidomide
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Low-dose nivolumab induced remission in refractory classical Hodgkin lymphoma
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Cytomegalovirus retinitis complicating combination therapy with rituximab and fludarabine
Cytomegalovirus (CMV) retinitis is exceptionally rare outside the clinical context of acquired immunodeficiency syndrome and organ allografting. In a population where seropositivity for past CMV infection exce...
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Article
Unilateral hearing loss due to lymphocytosis and a contralateral putamen lesion
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Breakthrough invasive fungal diseases during echinocandin treatment in high-risk hospitalized hematologic patients
The frequency of breakthrough invasive fungal diseases (IFDs) during echinocandin therapy is unclear. We retrospectively analyzed 534 hematologic patients treated with echinocandin (caspofungin, N = 55; micafungi...
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Open AccessHistiocytic sarcoma simulating immune thrombocytopenic purpura
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Open AccessDisseminated Langerhans cell histiocytosis associated with acute myeloid leukaemia: complete remission with daunorubicin and cytarabine
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Open AccessPrimary immune thrombocytopenia responding to antithyroid treatment in a patient with Graves’ disease
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Post-rituximab Burkitt transformation of PTLD: loss of CD20 expression accompanied by a switch in light-chain expression
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Author reply: Bortezomib and restoration of chemosensitivity
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Restoration of chemosensitivity by bortezomib: implications for refractory myeloma
Resistance to chemotherapy remains one of the major challenges in the treatment of patients with multiple myeloma. Chim et al. report the case of a 59-year-old woman with multiple myeloma, who progressed after tr...