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    Article

    Lysophosphatidylcholine Acyltransferase 1 Deficiency Promotes Pulmonary Emphysema via Apoptosis of Alveolar Epithelial Cells

    Chronic obstructive pulmonary disease (COPD) is primarily caused by inhalation of cigarette smoke and is the third leading cause of death worldwide. Pulmonary surfactant, a complex of phospholipids and protein...

    Takae Tanosaki, Yu Mikami, Hideo Shindou, Tomoyuki Suzuki in Inflammation (2022)

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    SARS-CoV-2 infection of the oral cavity and saliva

    Despite signs of infection—including taste loss, dry mouth and mucosal lesions such as ulcerations, enanthema and macules—the involvement of the oral cavity in coronavirus disease 2019 (COVID-19) is poorly und...

    Ni Huang, Paola Pérez, Takafumi Kato, Yu Mikami, Kenichi Okuda in Nature Medicine (2021)

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    Open Access

    TAZ contributes to pulmonary fibrosis by activating profibrotic functions of lung fibroblasts

    Transcriptional coactivator with PDZ-binding motif (TAZ) regulates a variety of biological processes. Nuclear translocation and activation of TAZ are regulated by multiple mechanisms, including actin cytoskele...

    Satoshi Noguchi, Akira Saito, Yu Mikami, Hirokazu Urushiyama in Scientific Reports (2017)