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  1. Article

    Open Access

    Hierarchical Cluster and Region of Interest Analyses Based on Mass Spectrometry Imaging of Human Brain Tumours

    Imaging mass spectrometry (IMS) has been rarely used to examine specimens of human brain tumours. In the current study, high quality brain tumour samples were selected by tissue observation. Further, IMS analy...

    Takuya Hiratsuka, Yoshiki Arakawa, Yuka Yajima, Yu Kakimoto in Scientific Reports (2020)

  2. Article

    Open Access

    Myocardial lipofuscin accumulation in ageing and sudden cardiac death

    Lipofuscin is an intracellular aggregate of highly oxidized proteins that cannot be digested in the ubiquitin-proteasome system and accumulate mainly in lysosomes, especially in aged cells and pathological con...

    Yu Kakimoto, Chisa Okada, Noboru Kawabe, Ayumi Sasaki in Scientific Reports (2019)

  3. Article

    Open Access

    Region of Interest analysis using mass spectrometry imaging of mitochondrial and sarcomeric proteins in acute cardiac infarction tissue

    Matrix-assisted laser desorption ionization image mass spectrometry (MALDI-IMS) has been developed for the identification of peptides in various tissues. The MALDI-IMS signal distribution patterns and quantifi...

    Yuka Yajima, Takuya Hiratsuka, Yu Kakimoto, Shuichiro Ogawa in Scientific Reports (2018)