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2,168 Result(s)
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Article
Restoration of degraded alpine meadows from the perspective of plant–soil feedbacks
Understanding the plant–soil feedbacks (PSFs) of dominant species of alpine meadow under different degradation status could provide insights into sustainable restoration. The direction, strength, and influenci...
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Open AccessNew advances of NG2-expressing cell subset in marrow mesenchymal stem cells as novel therapeutic tools for liver fibrosis/cirrhosis
Bone marrow-derived mesenchymal stem cell (BMMSC)-based therapy has become a major focus for treating liver fibrosis/cirrhosis. However, although these cell therapies promote the treatment of this disease, the he...
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Open AccessHoney bee (Apis cerana) queen rearing methods influence queen morphological characteristics and reproductive related gene expression
The quality of the queen is crucial for the survival and growth of honey bee colonies. There have been studies related to raising queens with excellent performance since the invention of artificial queen reari...
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Pannonibacter tanglangensis sp. nov., a New Species Isolated from Pond Sediment
Two bacterial strains (XCT-34T and XCT-53) isolated from sediment samples of an artificial freshwater reservoir were analyzed using a polyphasic approach. The two isolates are aerobic, Gram-stain-negative, oxidas...
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Chalcomoracin promotes apoptosis and endoplasmic reticulum stress in hepatocellular carcinoma cells
Chalcomoracin (CMR), a Diels-Alder adduct obtained from mulberry leaves, demonstrated wide-spectrum anti-cancer activity. Herein, we aimed to explore the function of CMR and how it works in hepatocellular carc...
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Open AccessGenetic Prediction of Osteoporosis by Anti-Müllerian Hormone Levels and Reproductive Factors in Women: A Mendelian Randomization Study
Previous observational studies have suggested that anti-Müllerian hormone (AMH) and reproductive factors are linked to reduced bone mineral density (BMD) and an increased risk of osteoporosis (OP) in women. Ho...
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Nitrogen supply influences photosynthetic acclimation of yellow birch (Betula costata Trautv.) to the combination of elevated CO2 and warmer temperature
Rising CO2, global warming, and N deposition create challenging environmental conditions to vegetation. Since elevated CO2 and rising temperature are coupled with each other, it is important to understand their c...
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Open AccessAnaplastic Lymphoma Kinase signaling stabilizes SLC3A2 expression via MARCH11 to promote neuroblastoma cell growth
Solute Carrier Family 3, Member 2 (SLC3A2 or 4F2hc) is a multifunctional glycoprotein that mediates integrin-dependent signaling, acts as a trafficking chaperone for amino acid transporters, and is involved in...
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A network analysis of external shocks on the dynamics and resilience of the global staple food trade
International food trade plays a crucial role in enhancing global food security by connecting regions with diverse agricultural capabilities and resource endowments. This study employs complex network analysis...
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Open AccessGeneration and transcriptomic characterization of MIR137 knockout miniature pig model for neurodevelopmental disorders
Neurodevelopmental disorders (NDD), such as autism spectrum disorders (ASD) and intellectual disorders (ID), are highly debilitating childhood psychiatric conditions. Genetic factors are recognized as playing ...
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Article
Open AccessDeciphering spatial domains from spatial multi-omics with SpatialGlue
Advances in spatial omics technologies now allow multiple types of data to be acquired from the same tissue slice. To realize the full potential of such data, we need spatially informed methods for data integr...
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Open AccessReprogramming of 3D genome structure underlying HSPC development in zebrafish
Development of hematopoietic stem and progenitor cells (HSPC) is a multi-staged complex process that conserved between zebrafish and mammals. Understanding the mechanism underlying HSPC development is a holy g...
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Open AccessCorrection: Evaluation of clinical characteristics and risk factors associated with Chlamydia psittaci infection based on metagenomic next-generation sequencing
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Advances in the Study of Etiology and Molecular Mechanisms of Sensorineural Hearing Loss
Sensorineural hearing loss (SNHL), a multifactorial progressive disorder, results from a complex interplay of genetic and environmental factors, with its underlying mechanisms remaining unclear. Several pathol...
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Effects of Humic Acid-Copper Interactions on Growth, Nutrient Absorption, and Photosynthetic Performance of Citrus sinensis Seedlings in Sand Culture
In China, high copper (Cu) and low organic matter often occur in some citrus orchard soils. However, the underlying mechanisms by which humic acid (HA) stimulates growth and mitigates Cu toxicity of citrus see...
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In vivo transgenic studies confirm the critical acylation function of LeBAHD56 for shikonin in Lithospermum erythrorhizon
LeBAHD56 is preferentially expressed in tissues where shikonin and its derivatives are biosynthesized, and it confers shikonin acylation in vivo. Two WRKY transcriptional factors might regulate LeBAHD56’s express...
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Open AccessCorrection: Conformational characterization of the mammalian-expressed SARS-CoV-2 recombinant receptor binding domain, a COVID-19 vaccine
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Article
Association of biological aging with frailty and post-transplant outcomes among adults with cirrhosis
Frailty is classically associated with advanced age but is also an important predictor of clinical outcomes in comparatively young adults with cirrhosis. We examined the association of biological aging with fr...
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Lineage regulators TFAP2C and NR5A2 function as bipotency activators in totipotent embryos
During the first lineage segregation, a mammalian totipotent embryo differentiates into the inner cell mass (ICM) and trophectoderm (TE). However, how transcription factors (TFs) regulate this earliest cell-fa...
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Map** putative enhancers in mouse oocytes and early embryos reveals TCF3/12 as key folliculogenesis regulators
Dynamic epigenomic reprogramming occurs during mammalian oocyte maturation and early development. However, the underlying transcription circuitry remains poorly characterized. By map** cis-regulatory elements u...