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Article
Open AccessAmyloidogenic, neuroinflammatory and memory dysfunction effects of HIV-1 gp120
Human immunodeficiency virus 1 (HIV-1) infection can cause several HIV-associated neurocognitive disorders a variety of neurological impairments characterized by the loss of cortical and subcortical neurons an...
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Article
Open AccessAnti-inflammatory and anti-amyloidogenic effects of a small molecule, 2,4-bis(p-hydroxyphenyl)-2-butenal in Tg2576 Alzheimer’s disease mice model
Alzheimer’s disease (AD) is pathologically characterized by excessive accumulation of amyloid-beta (Aβ) fibrils within the brain and activation of astrocytes and microgl...
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Article
Attenuation of scopolamine-induced cognitive dysfunction by obovatol
Alzheimer’s disease (AD) is the most prevalent cause of dementia in the elderly people. The disease is pathologically characterized by extracellular deposition of beta-amyloid peptide (Aβ), cholinergic neurode...
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Article
Open AccessInhibitory effect of 4-O-methylhonokiol on lipopolysaccharide-induced neuroinflammation, amyloidogenesis and memory impairment via inhibition of nuclear factor-kappaB in vitro and in vivo models
Neuroinflammation is important in the pathogenesis and progression of Alzheimer disease (AD). Previously, we demonstrated that lipopolysaccharide (LPS)-induced neuroinflammation caused memory impairments. In t...
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Article
Open AccessInhibitory effect of a tyrosine-fructose Maillard reaction product, 2,4-bis(p-hydroxyphenyl)-2-butenal on amyloid-β generation and inflammatory reactions via inhibition of NF-κB and STAT3 activation in cultured astrocytes and microglial BV-2 cells
Amyloidogenesis is linked to neuroinflammation. The tyrosine-fructose Maillard reaction product, 2,4-bis(p-hydroxyphenyl)-2-butenal, possesses anti-inflammatory properties in cultured macrophages, and in an arthr...
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Article
Effects of thermal stress induced by cyclic heat treatment on sintered (Nd, Dy)-Fe-B magnets
We investigated the mechanisms of coercive force enhancement on Nd11Dy4Fe76.5TM2.5B6 (TM = Co, Cu, Al) induced by a number of cyclic heat treatments (CHT) at temperatures from 350°C to 450°C. The difference in th...
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Article
Magnetic properties of high coercivity Nd23Dy10Fe64TM2B1 sintered magnets by a convergent heat treatment
The magnetic property of Nd23Dy10Fe64TM2B1 alloy was investigated by the convergent heat treatment at 350 to 450°C with the heating/cooling rate of 10°C/min in vacuum (10−5 Torr). The convergent heat treatment wa...
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Article
Inflammation and Alzheimer’s disease
Alzheimer’s disease (AD) is the most common form of dementia. It is characterized by extracellular deposition of a specific protein, beta-amyloid peptide fibrils, and is accompanied by extensive loss of neuron...
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Article
Open AccessInhibitory Effect of 1-O-Hexyl-2,3,5-Trimethylhydroquinone on Dimethylnitrosamine-induced Liver Fibrosis in Male SD Rats
Hepatic fibrosis represents the main complication of most chronic liver disorders and, regardless of its etiology, is characterized by excessive deposition of extracellular matrix components. In this study, we...
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Article
Hybridized porous structure of Al alloy by surface modification of pores
To improve the filtration efficiency of porous materials used in filters, an extensive specific surface area is required to serve as a site for adsorption with impurities. In this paper, a method for creating ...
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Article
Optical properties of molybdenum oxide thin films deposited by chemical vapor transport of MoO3(OH)2
MoO3 thin films are useful for optical devices due to their electrochromic properties. In this study, deposition of MoO2 thin films was successfully accomplished by chemical vapor transport (CVT) of volatile MoO3
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Article
Detection of 14 alleles derived from the MHC class I A locus in cynomolgus monkeys
A basic understanding of the major histocompatibility complex (MHC) class I, which, together with T-cell receptors, is a key player in antigen recognition by cytotoxic T lymphocytes, is necessary to study the ...
