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  1. Article

    Open Access

    CKD-506, a novel HDAC6-selective inhibitor, improves renal outcomes and survival in a mouse model of systemic lupus erythematosus

    Systemic lupus erythematosus (SLE) is a chronic multisystemic autoimmune disease with an unknown etiology. Recently, it has been elucidated that dysregulated histone deacetylase (HDAC) activity is related to t...

    Eun Wha Choi, Ji Woo Song, Nina Ha, Young Il Choi, Sungjoo Kim in Scientific Reports (2018)

  2. Article

    Open Access

    Structural Basis for the Enhanced Anti-Diabetic Efficacy of Lobeglitazone on PPARγ

    Peroxisome proliferator-activated receptor γ (PPARγ) is a member of the nuclear receptor superfamily. It functions as a ligand-activated transcription factor and plays important roles in the regulation of adip...

    Jun Young Jang, Hwan Bae, Yong Jae Lee, Young Il Choi, Hyun-Jung Kim in Scientific Reports (2018)