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Article
Open AccessInhibition of histone deacetylase 6 suppresses inflammatory responses and invasiveness of fibroblast-like-synoviocytes in inflammatory arthritis
To investigate the effects of inhibiting histone deacetylase (HDAC) 6 on inflammatory responses and tissue-destructive functions of fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA).
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Article
Open AccessTherapeutic potential of CKD-506, a novel selective histone deacetylase 6 inhibitor, in a murine model of rheumatoid arthritis
Histone deacetylase (HDAC) 6 promotes inflammation. We investigated the anti-arthritic effects of CKD-506, a novel HDAC6 inhibitor, in vitro and in a murine model of arthritis as a novel treatment option for r...
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Article
Validation of the prognostic performance in various nodal staging systems for gallbladder cancer: results of a multicenter study
Although the current nodal staging system for gallbladder cancer (GBC) was changed based on the number of positive lymph nodes (PLN), it needs to be evaluated in various situations.
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Article
Open AccessCKD-506, a novel HDAC6-selective inhibitor, improves renal outcomes and survival in a mouse model of systemic lupus erythematosus
Systemic lupus erythematosus (SLE) is a chronic multisystemic autoimmune disease with an unknown etiology. Recently, it has been elucidated that dysregulated histone deacetylase (HDAC) activity is related to t...
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Article
Open AccessStructural Basis for the Enhanced Anti-Diabetic Efficacy of Lobeglitazone on PPARγ
Peroxisome proliferator-activated receptor γ (PPARγ) is a member of the nuclear receptor superfamily. It functions as a ligand-activated transcription factor and plays important roles in the regulation of adip...
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Article
Open AccessTherapeutic effect of a novel histone deacetylase 6 inhibitor, CKD-L, on collagen-induced arthritis in vivo and regulatory T cells in rheumatoid arthritis in vitro
Histone deacetylase (HDAC) inhibitor has recently been reported to have a therapeutic effect as an anti-inflammatory agent in collagen-induced arthritis (CIA). We investigated the therapeutic effect of a new s...
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Article
Cytomegalovirus infection-associated fulminant hepatitis in an immunocompetent adult requiring emergency living-donor liver transplantation: report of a case
Human cytomegalovirus (CMV) infection is usually self-limiting in healthy adults, but it can lead to significant complications. This report presents the case of an immunocompetent adult with fulminant hepatiti...
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Article
Super-selection of a Subgroup of Hepatocellular Carcinoma Patients at Minimal Risk of Recurrence for Liver Transplantation
A majority of patients with hepatocellular carcinoma (HCC) undergoing liver transplantation (LT) meet the Milan criteria, but these are still regarded as the narrowest criteria for transplantation. Prognostic ...
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Chapter and Conference Paper
Tightly Packed IP Address Configuration (TPIA) Protocol in Small-Scale MANET
Configuring IP addresses is an important issue in ad-hoc networks without a centralized agent server. The previous configuration methods result in wasted IP addresses, and are unsuitable for assigning addresse...
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Chapter and Conference Paper
Generating Test Cases for Web Services Using Extended Finite State Machine
Web services utilize a standard communication infrastructure such as XML and SOAP to communicate through the Internet. Even though Web services are becoming more and more widespread as an emerging technology, ...
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Chapter and Conference Paper
Open Software Architecture for Multiservice Switching System
To meet the rigorous demands of today’s fast-moving telecommunication environment, every carriers want to deploy new services smoothly with minimal impact on the underlying infrastructure. Also it is necessary...
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Chapter and Conference Paper
An Integrated Data Model and a Query Language for Content- Based Retrieval of Video
As video data have been used in multimedia information systems, the need for the database support that provides an efficient way for users to retrieve video data is growing. In this paper, we propose a video d...
