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Modification of DBC1 by SUMO2/3 is crucial for p53-mediated apoptosis in response to DNA damage

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  1. Article

    Open Access

    Positive feedback regulation of p53 transactivity by DNA damage-induced ISG15 modification

    p53 plays a pivotal role in tumour suppression under stresses, such as DNA damage. ISG15 has been implicated in the control of tumorigenesis. Intriguingly, the expression of ISG15, UBE1L and UBCH8 is induced b...

    Jong Ho Park, Seung Wook Yang, Jung Mi Park, Seung Hyeun Ka… in Nature Communications (2016)

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  2. Article

    Open Access

    Genetic variants in 3′-UTRs of methylenetetrahydrofolate reductase (MTHFR) predict colorectal cancer susceptibility in Koreans

    Polymorphisms in the methylenetetrahydrofolate reductase (MTHFR) play important roles in tumor development, progression and metastasis. Moreover, recent studies have reported that a number of 3′-UTR polymorphisms...

    Young Joo Jeon, Jong Woo Kim, Hye Mi Park, Jung O Kim, Hyo Geun Jang… in Scientific Reports (2015)

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