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Article
Roles of integrins in regulating metastatic potentials of cancer cell derived exosomes
Purpose of review: Exosomes are nano-sized extracellular vesicles ranging from 30–150 nm in diameter. Exosomes interact with nearby or distantly localized recipient cells by involving ligand/receptor binding at t...
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Article
Open AccessEpigenetic silencing of ARRDC3 expression in basal-like breast cancer cells
Arrestin domain-containing 3 (ARRDC3) is a tumor suppressor whose expression is either lost or suppressed in basal-like breast cancer (BLBC). However, the mechanism by which BLBC suppresses ARRDC3 expression i...
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Article
Open AccessThe role of c-Src in integrin (α6β4) dependent translational control
Integrin α6β4 contributes to cancer progression by stimulating transcription as well as translation of cancer related genes. Our previous study demonstrated that α6β4 stimulates translation initiation of survi...
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Article
Mutational analysis of EGFR and K-RAS genes in lung adenocarcinomas
Both epidermal growth factor receptor (EGFR) and RAS gene mutations contribute to the development of non-small cell lung cancer (NSCLC). Because RAS is one of the downstream molecules in the EGFR signal transduct...
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Article
PIK3CA gene is frequently mutated in breast carcinomas and hepatocellular carcinomas
A recent report revealed that phosphoinositide-3-kinase, catalytic, alpha (PIK3CA) gene is somatically mutated in several types of human cancer, suggesting the mutated PIK3CA gene as an oncogene in human cancers....
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Article
Caspase-8 gene is frequently inactivated by the frameshift somatic mutation 1225_1226delTG in hepatocellular carcinomas
Evidence exists that alterations of the genes encoding apoptosis-related proteins contribute to either development or progression of human cancers. Caspase-8 plays a crucial role in the initiation phase of apo...
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Article
Establishment ofin vitro test system for the evaluation of the estrogenic activities of natural products
In order to evaluate estrogenic compounds in natural products, anin vitro detection system was established. For this system, the human breast cancer cell line MCF7 was stably transfected using an estrogen respons...
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Article
Somatic mutations of CASP3 gene in human cancers
Failure of apoptosis is one of the hallmarks of cancer. As an execution-phase caspase, caspase-3 plays a crucial role during apoptosis. To explore the possibility that the genetic alterations of CASP3, which e...
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Article
BRAF and KRAS mutations in stomach cancer
Ras proteins control signaling pathways that are key regulators of several aspects of normal cell growth and malignant transformation. BRAF, which encodes a RAF family member in the downstream pathway of RAS, is ...
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Article
Inactivating mutations of CASPASE-7 gene in human cancers
Caspase-7 is a caspase involved in the execution phase of apoptosis. To explore the possibility that the genetic alterations of CASPASE-7 might be involved in the development of human cancers, we analysed the ent...
