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  1. Article

    Open Access

    Prime editing with genuine Cas9 nickases minimizes unwanted indels

    Unlike CRISPR-Cas9 nucleases, which yield DNA double-strand breaks (DSBs), Cas9 nickases (nCas9s), which are created by replacing key catalytic amino-acid residues in one of the two nuclease domains of S. pyog...

    Jaesuk Lee, Kayeong Lim, Annie Kim, Young Geun Mok, Eugene Chung… in Nature Communications (2023)

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  2. Article

    Open Access

    Targeted A-to-G base editing of chloroplast DNA in plants

    Chloroplast DNA (cpDNA) encodes up to 315 (typically, 120–130) genes1, including those for essential components in photosystems I and II and the large subunit of RuBisCo, which catalyses CO2 fixation in plants. T...

    Young Geun Mok, Sunghyun Hong, Su-Ji Bae, Sung-Ik Cho, **-Soo Kim in Nature Plants (2022)

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  3. Article

    Open Access

    Base editing in human cells with monomeric DddA-TALE fusion deaminases

    Inter-bacterial toxin DddA-derived cytosine base editors (DdCBEs) enable targeted C-to-T conversions in nuclear and organellar DNA. DddAtox, the deaminase catalytic domain derived from Burkholderia cenocepacia, i...

    Young Geun Mok, Ji Min Lee, Eugene Chung, Jaesuk Lee, Kayeong Lim… in Nature Communications (2022)

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  4. Article

    Open Access

    DEMETER plant DNA demethylase induces antiviral response by interferon signalling in animal cells

    DNA methylation is a prominent epigenetic modification in plants and animals regulated by similar mechanisms but the process of DNA demethylation is profoundly different. Unlike vertebrates that require a seri...

    Young Geun Mok, Ki Young Choi, Seung Hwan Hong, ** Hoe Huh in Scientific Reports (2017)

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