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  1. Article

    Correction to: Combined viral quasispecies diversity and hepatitis B core-related antigen predict off-nucleos(t)ide analog durability in HBeAg-negative patients

    Huei-Ru Cheng, Hung-Chih Yang, Su-Ru Lin, Ta-Yu Yang in Hepatology International (2021)

  2. No Access

    Article

    Combined viral quasispecies diversity and hepatitis B core-related antigen predict off-nucleos(t)ide analog durability in HBeAg-negative patients

    Viral quasispecies dynamics between pre- and post-nucleos(t)ide analog (NA) therapy remains unclear.

    Huei-Ru Cheng, Hung-Chih Yang, Su-Ru Lin, Ta-Yu Yang in Hepatology International (2021)

  3. Article

    Open Access

    HBV X protein-based therapeutic vaccine accelerates viral antigen clearance by mobilizing monocyte infiltration into the liver in HBV carrier mice

    Hepatitis B virus (HBV) persistently infected about 250 million people worldwide, and a curative treatment remains an unmet medical need. Among many approaches to treat chronic hepatitis B (CHB), therapeutic v...

    Jau-Hau Horng, Wei-Hsiang Lin, Chang-Ru Wu, You-Yu Lin in Journal of Biomedical Science (2020)

  4. Article

    Open Access

    De novo assembly of highly polymorphic metagenomic data using in situ generated reference sequences and a novel BLAST-based assembly pipeline

    The accuracy of metagenomic assembly is usually compromised by high levels of polymorphism due to divergent reads from the same genomic region recognized as different loci when sequenced and assembled together...

    You-Yu Lin, Chia-Hung Hsieh, Jiun-Hong Chen, Xuemei Lu, Jia-Horng Kao in BMC Bioinformatics (2017)

  5. No Access

    Article

    Synthesis and anti-cancer activity of a glycosyl library of \(\varvec{N}\) -acetylglucosamine-bearing oleanolic acid

    N-Acetylglucosamine-bearing triterpenoid saponins (GNTS) were reported to be a unique type of saponins with potent anti-tumor activity. In order to study the structure–activity relationship of GN...

    Yi-Bing Zeng, Hsin-Min Hsiao, She-Hung Chan, Ying-Hsin Wang in Molecular Diversity (2014)

  6. Article

    Open Access

    Fosmid library end sequencing reveals a rarely known genome structure of marine shrimp Penaeus monodon

    The black tiger shrimp (Penaeus monodon) is one of the most important aquaculture species in the world, representing the crustacean lineage which possesses the greatest species diversity among marine invertebrate...

    Shiao-Wei Huang, You-Yu Lin, En-Min You, Tze-Tze Liu, Hung-Yu Shu in BMC Genomics (2011)

  7. Article

    Single cell transcriptome analysis upon MCF-7 breast cancer

    Yih-Shien Chiang, Lock Ying Seng, You-Yu Lin, Shih-Hao Chen, Yu-Chang Su in Genome Biology (2010)