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Article
Toxicity assessment of Gryllus bimaculatus (a type of cricket) glycosaminoglycan
We performed general toxicity studies of Gryllus bimaculatus (two-spotted cricket) glycosaminoglycan (GbG), including a single, 4-week repeated oral dose toxicity test in ICR mice, and short-term genotoxicity tes...
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Article
Comparison of the Physical Properties and in vivo Bioactivities of Flatwise-Spun Silk Mats and Cocoon-Derived Silk Mats for Guided Bone Regeneration
The main flaw of silkworm cocoon originated membranes for guided bone regeneration (GBR) techniques is that the maximum size of the membrane is determined by the size of the cocoon. Flatwise-spun silk does not...
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Article
Open AccessRetrospective comparative clinical study for silk mat application into extraction socket
Silk mats have been approved for clinical trials by the Korean Food and Drug Administration as membranes for guided tissue regeneration (GTR). In this study, silk mat application was compared to high-density p...
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Article
Open Access4-Hexylresorcinol and silk sericin increase the expression of vascular endothelial growth factor via different pathways
Angiogenesis plays an important role in active inflammation and wound healing. Our results showed that silk sericin and 4-hexylresorcinol (4HR) increased vascular endothelial growth factor (VEGF) expression in...
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Article
Open AccessThe effects of proteins released from silk mat layers on macrophages
The objective of this study was to evaluate the changes in gene expression after incubation of cells with proteins released from different silk mat layers.
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Article
Open AccessBone regeneration is associated with the concentration of tumour necrosis factor-α induced by sericin released from a silk mat
To understand the osteogenic effect of the middle layer of the silk cocoon, sericin was examined for its cellular effects associated with tumor necrosis factor-α (TNF-α) signaling in this study. The fragmented...
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Article
In vivo bone regeneration ability of different layers of natural silk cocoon processed using an eco-friendly method
Silk cocoons are primarily composed of the proteins fibroin and sericin. To achieve guided bone regeneration (GBR), we have developed a simple and ecofriendly processing technique to obtain microperforated thi...
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Article
Comparison of Bio-degradation for Ridge Preservation Using Silk Fibroin-based Grafts and a Collagen Plug
A material for ridge preservation should have dimensional stability to resist bio-degradation. This study was designed to compare bio-degradation of ridge preservation materials. Collagen plug was used as a po...
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Article
Open AccessAccelerated biodegradation of silk sutures through matrix metalloproteinase activation by incorporating 4-hexylresorcinol
Silk suture material is primarily composed of silk fibroin and regarded as a non-resorbable material. It is slowly degraded by proteolysis when it is implanted into the body. 4-Hexylresorcinol (4HR) is a well-...
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Article
Open AccessS100 and p65 expression are increased in the masseter muscle after botulinum toxin-A injection
The purpose of this study was to compare the expression levels of p65 and S100 in the rat masseter muscle after the injection of different concentrations of botulinum toxin-A (BTX-A).
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Article
Open AccessComparison of unprocessed silk cocoon and silk cocoon middle layer membranes for guided bone regeneration
Silk cocoon is composed of multiple layers. The natural silk cocoon containing all layers was cut as a rectangular shape as defined as total group. The inner and outermost layers were removed from the total gr...
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Article
Comparison of different concentrations of tetracycline-loaded silk fibroin membranes on the guided bone regeneration in the rat calvarial defect model
The objective of this study was to evaluate bone regeneration ability using different concentrations of tetracycline (TC) loaded into silk fibroin membranes (SFMs). Prior to animal experiments, MTT assays and ...
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Article
Comparison of the physical properties and in vivo bioactivities of silkworm-cocoon-derived silk membrane, collagen membrane, and polytetrafluoroethylene membrane for guided bone regeneration
The aim of this study was to evaluate silkworm-cocoon-derived silk membrane (SM) for application in guided bone regeneration (GBR) and to compare it with commercially available GBR membranes, such as collagen ...
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Article
Evaluation of thein vivo antithrombotic, anticoagulant and fibrinolytic activities ofLumbricus rubellus earthworm powder
A saline suspension ofLumbricus rubellus earthworm powder (EWP) was administered to rats (1 g/kg/day) orally for 15 days to evaluate an oral effectiveness for thrombotic disorders. Blood was drawn at 2-day interv...
