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Article
Open AccessAssociation between the COVID-19 pandemic and childhood development aged 30 to 36 months in South Korea, based on the National health screening program for infants and children database
The coronavirus disease 2019 (COVID-19) pandemic has had a significant impact on the neurodevelopment of children. However, the precise effects of the virus and the social consequences of the pandemic on pedia...
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Article
Open AccessSIRT1 ISGylation accelerates tumor progression by unleashing SIRT1 from the inactive state to promote its deacetylase activity
ISG15 is an interferon-stimulated ubiquitin-like protein (UBL) with multifaceted roles as a posttranslational modifier in ISG15 conjugation (ISGylation). However, the mechanistic consequences of ISGylation in ...
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Article
Open AccessDevelopment of a deep learning model that predicts critical events of pediatric patients admitted to general wards
Early detection of deteriorating patients is important to prevent life-threatening events and improve clinical outcomes. Efforts have been made to detect or prevent major events such as cardiopulmonary resusci...
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Article
Open AccessClinical importance of weight gain and associated factors in patients with moderate to severe ulcerative colitis: results from the MOSAIK cohort in Korea
Many patients with ulcerative colitis (UC) gain weight after treatment. However, the clinical significance of weight gain in these patients remains unclear. This study aimed to evaluate body weight changes aft...
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Article
Open AccessPrimary sclerosing cholangitis (PSC) and inflammatory bowel disease (IBD): a condition exemplifying the crosstalk of the gut–liver axis
The close relationship between primary sclerosing cholangitis (PSC) and inflammatory bowel disease (IBD) provides a good opportunity to comprehend the gut–liver axis. The gut and the liver have reciprocal inte...
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Article
Open AccessPatient and hospital characteristics predict prolonged emergency department length of stay and in-hospital mortality: a nationwide analysis in Korea
Prolonged emergency department length of stay (EDLOS) in critically ill patients leads to increased mortality. This nationwide study investigated patient and hospital characteristics associated with prolonged ...
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Article
Open AccessRoles of RIPK3 in necroptosis, cell signaling, and disease
Receptor-interacting protein kinase-3 (RIPK3, or RIP3) is an essential protein in the “programmed” and “regulated” cell death pathway called necroptosis. Necroptosis is activated by the death receptor ligands ...
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Open AccessHarnessing novel engineered feeder cells expressing activating molecules for optimal expansion of NK cells with potent antitumor activity
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Open AccessRIPK3 activation induces TRIM28 derepression in cancer cells and enhances the anti-tumor microenvironment
Necroptosis is emerging as a new target for cancer immunotherapy as it is now recognized as a form of cell death that increases tumor immunogenicity, which would be especially helpful in treating immune-desert...
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Article
Open AccessDevelopment of a machine learning model for predicting pediatric mortality in the early stages of intensive care unit admission
The aim of this study was to develop a predictive model of pediatric mortality in the early stages of intensive care unit (ICU) admission using machine learning. Patients less than 18 years old who were admitt...
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Article
Open AccessReduction in MLKL-mediated endosomal trafficking enhances the TRAIL-DR4/5 signal to increase cancer cell death
Mixed lineage kinase domain-like (MLKL) is an essential molecule of necroptosis, a cell death process that is initiated by direct disruption of the plasma membrane. During necroptosis, MLKL is phosphorylated b...
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Article
Open AccessThe role of FGF-2 in smoke-induced emphysema and the therapeutic potential of recombinant FGF-2 in patients with COPD
Although the positive effects of recombinant fibroblast growth factor-2 (rFGF-2) in chronic obstructive pulmonary disease (COPD) have been implicated in previous studies, knowledge of its role in COPD remains ...
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Article
Open AccessThe chromatin remodeler RSF1 controls centromeric histone modifications to coordinate chromosome segregation
Chromatin remodelers regulate the nucleosome barrier during transcription, DNA replication, and DNA repair. The chromatin remodeler RSF1 is enriched at mitotic centromeres, but the functional consequences of t...
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Article
Open AccessHS-1371, a novel kinase inhibitor of RIP3-mediated necroptosis
Necroptosis is a type of programmed cell death that usually occurs under apoptosis-deficient conditions. Receptor-interacting protein kinase-3 (RIP3, or RIPK3) is a central player in necroptosis, and its kinas...
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Differential Diagnosis of Inflammatory Bowel Disease: Endoscopic Findings and Diagnosis of Intestinal Tuberculosis
The diagnosis of intestinal tuberculosis (TB) must consider the clinical, laboratory, endoscopic, and histological features, and should be categorized as a definitive or probable diagnosis. Definitive intestin...
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Article
Proteomic Analysis of Serum Amyloid A as a Potential Marker in Intestinal Behçet’s Disease
Data regarding biomarkers to understand disease pathogenesis and to assess disease activity of intestinal Behçet’s disease (BD) are limited. Therefore, we aimed to investigate the differentially expressed prot...
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Article
Open AccessNuclear TRADD prevents DNA damage-mediated death by facilitating non-homologous end-joining repair
TNF receptor-associated death domain (TRADD) is an essential mediator of TNF receptor signaling, and serves as an adaptor to recruit other effectors. TRADD has been shown to cycle between the cytoplasm and nuc...
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Article
Open AccessThe microbiome of the lung and its extracellular vesicles in nonsmokers, healthy smokers and COPD patients
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease, and bacterial infection plays a role in its pathogenesis. Bacteria secrete nanometer-sized extracellular vesicles (EVs), which ma...
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Article
Open AccessAutophagic flux, a possible mechanism for delayed gentamicin-induced ototoxicity
Aminoglycoside antibiotics including gentamicin (GM) induce delayed ototoxic effects such as hearing loss after long-term use, unlike the early-onset ototoxicity caused by cisplatin. The purpose of the study w...
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Article
Open AccessAdipose stem cell-derived nanovesicles inhibit emphysema primarily via an FGF2-dependent pathway
Cell therapy using stem cells has produced therapeutic benefits in animal models of COPD. Secretory mediators are proposed as one mechanism for stem cell effects because very few stem cells engraft after injec...
