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  1. Article

    Open Access

    A case study of lean digital transformation through robotic process automation in healthcare

    Under Taiwan's National Health Insurance (NHI) system, it's crucial for all healthcare providers to accurately submit medical expense claims to the National Health Insurance Administration (NHIA) to avoid inco...

    Wei-Lun Huang, Shu-Lang Liao, Hsueh-Ling Huang, You-Xuan Su in Scientific Reports (2024)

  2. Article

    Open Access

    Low pressure reversibly driving colossal barocaloric effect in two-dimensional vdW alkylammonium halides

    Plastic crystals as barocaloric materials exhibit the large entropy change rivalling freon, however, the limited pressure-sensitivity and large hysteresis of phase transition hinder the colossal barocaloric ef...

    Yi-Hong Gao, Dong-Hui Wang, Feng-**a Hu, Qing-Zhen Huang in Nature Communications (2024)

  3. Article

    Open Access

    Dysfunction of duplicated pair rice histone acetyltransferases causes segregation distortion and an interspecific reproductive barrier

    Postzygotic reproductive isolation, which results in the irreversible divergence of species, is commonly accompanied by hybrid sterility, necrosis/weakness, or lethality in the F1 or other offspring generations. ...

    Ben Liao, You-Huang **ang, Yan Li, Kai-Yang Yang, Jun-**ang Shan in Nature Communications (2024)

  4. Article

    Open Access

    Diploid and tetraploid genomes of Acorus and the evolution of monocots

    Monocots are a major taxon within flowering plants, have unique morphological traits, and show an extraordinary diversity in lifestyle. To improve our understanding of monocot origin and evolution, we generate...

    Liang Ma, Ke-Wei Liu, Zhen Li, Yu-Yun Hsiao, Yiying Qi, Tao Fu in Nature Communications (2023)

  5. Article

    Open Access

    Use of dual genomic sequencing to screen mitochondrial diseases in pediatrics: a retrospective analysis

    Mitochondrial diseases (MDs) were a large group multisystem disorders, attributable in part to the dual genomic control. The advent of massively sequencing has improved diagnostic rates and speed, and was incr...

    Teng-Hui Wu, **g Peng, Li Yang, Yan-Hui Chen, **u-Lan Lu in Scientific Reports (2023)

  6. Article

    Open Access

    Evolutionary route of nasopharyngeal carcinoma metastasis and its clinical significance

    It is critical to understand factors associated with nasopharyngeal carcinoma (NPC) metastasis. To track the evolutionary route of metastasis, here we perform an integrative genomic analysis of 163 matched blo...

    Mei Lin, **ao-Long Zhang, Rui You, You-** Liu, Hong-Min Cai in Nature Communications (2023)

  7. Article

    Open Access

    MKL-1-induced PINK1-AS overexpression contributes to the malignant progression of hepatocellular carcinoma via ALDOA-mediated glycolysis

    Aldolase A (ALDOA), an important metabolic enzyme in the glycolytic pathway, plays an important role in regulating tumour metabolism. In this study, we investigated the expression pattern of ALDOA in hepatocel...

    Jun Wang, Hui-Min Zhang, Zhou-Tong Dai, You Huang, Hui Liu, Zhen Chen in Scientific Reports (2022)

  8. Article

    Open Access

    Avalanche photodiodes with multiple multiplication layers for coherent detection

    We demonstrate a novel avalanche photodiode (APD) design which fundamentally relaxes the trade-off between responsivity and saturation-current performance at receiver end in coherent system. Our triple In0.52Al0....

    Zohauddin Ahmad, Po-Shun Wang, Naseem, Yu-Cyuan Huang in Scientific Reports (2022)

  9. Article

    Open Access

    Photoredox cooperative N-heterocyclic carbene/palladium-catalysed alkylacylation of alkenes

    Three-component carboacylation of simple alkenes with readily available reagents is challenging. Transition metal-catalysed intermolecular carboacylation works for alkenes with strained ring or directing group...

    You-Feng Han, Ying Huang, Hao Liu, Zhong-Hua Gao, Chun-Lin Zhang in Nature Communications (2022)

  10. Article

    Open Access

    Short term outcomes of extremely low birth weight infants from a multicenter cohort study in Guangdong of China

    With the increase in extremely low birth weight (ELBW) infants, their outcome attracted worldwide attention. However, in China, the related studies are rare. The hospitalized records of ELBW infants discharged...

    Chun-Hong Jia, Zhou-Shan Feng, **ao-Jun Lin, Qi-Liang Cui in Scientific Reports (2022)

  11. Article

    Open Access

    Influences of dielectric constant and scan rate on hysteresis effect in perovskite solar cell with simulation and experimental analyses

    In this work, perovskite solar cells (PSCs) with different transport layers were fabricated to understand the hysteresis phenomenon under a series of scan rates. The experimental results show that the hysteres...

    Jun-Yu Huang, You-Wei Yang, Wei-Hsuan Hsu, En-Wen Chang in Scientific Reports (2022)

  12. Article

    Open Access

    Comprehensive profiling of 1015 patients’ exomes reveals genomic-clinical associations in colorectal cancer

    The genetic basis of colorectal cancer (CRC) and its clinical associations remain poorly understood due to limited samples or targeted genes in current studies. Here, we perform ultradeep whole-exome sequencin...

    Qi Zhao, Feng Wang, Yan-**ng Chen, Shifu Chen, Yi-Chen Yao in Nature Communications (2022)

  13. Article

    Open Access

    The quantum oscillations in different probe configurations in the \(\hbox {BiSbTe}_{{3}}\) topological insulator macroflake

    We demonstrate quantum oscillations in \(\hbox {BiSbTe}_{{3}}\) BiSbTe ...

    Shiu-Ming Huang, Chien Lin, Sheng-Yu You, You-Jhih Yan, Shih-Hsun Yu in Scientific Reports (2022)

  14. Article

    Open Access

    The active sites of Cu–ZnO catalysts for water gas shift and CO hydrogenation reactions

    Cu–ZnO–Al2O3 catalysts are used as the industrial catalysts for water gas shift (WGS) and CO hydrogenation to methanol reactions. Herein, via a comprehensive experimental and theoretical calculation study of a se...

    Zhenhua Zhang, Xuanye Chen, **can Kang, Zongyou Yu, Jie Tian in Nature Communications (2021)

  15. Article

    Open Access

    Impaired calcium signaling in astrocytes modulates autism spectrum disorder-like behaviors in mice

    Autism spectrum disorder (ASD) is a common neurodevelopmental disorder. The mechanisms underlying ASD are unclear. Astrocyte alterations are noted in ASD patients and animal models. However, whether astrocyte ...

    Qian Wang, Ying Kong, Ding-Yu Wu, Ji-Hong Liu, Wei Jie in Nature Communications (2021)

  16. Article

    Open Access

    Identification of potential therapeutic antimicrobial peptides against Acinetobacter baumannii in a mouse model of pneumonia

    Acinetobacter baumannii-induced nosocomial pneumonia has become a serious clinical problem because of high antibiotic resistance rates. Antimicrobial peptides (AMP) are an ideal alternative strategy due to their ...

    Chiau-**g Jung, You-Di Liao, Chih-Chieh Hsu, Ting-Yu Huang in Scientific Reports (2021)

  17. Article

    Open Access

    Orchid Bsister gene PeMADS28 displays conserved function in ovule integument development

    The ovules and egg cells are well developed to be fertilized at anthesis in many flowering plants. However, ovule development is triggered by pollination in most orchids. In this study, we characterized the fu...

    Ching-Yu Shen, You-Yi Chen, Ke-Wei Liu, Hsiang-Chia Lu in Scientific Reports (2021)

  18. Article

    Open Access

    Cryo-EM structure of an activated VIP1 receptor-G protein complex revealed by a NanoBiT tethering strategy

    Vasoactive intestinal polypeptide receptor (VIP1R) is a widely expressed class B G protein-coupled receptor and a drug target for the treatment of neuronal, metabolic, and inflammatory diseases. However, our u...

    Jia Duan, Dan-dan Shen, X. Edward Zhou, Peng Bi, Qiu-feng Liu in Nature Communications (2020)

  19. Article

    Open Access

    Elevation in the counts of IL-35-producing B cells infiltrating into lung tissue in mycobacterial infection is associated with the downregulation of Th1/Th17 and upregulation of Foxp3+Treg

    IL-35 is an anti-inflammatory cytokine and is thought to be produced by regulatory T (Treg) cells. A previous study found that IL-35 was upregulated in the serum of patients with active tuberculosis (ATB), and...

    Chen Chen, Huan Xu, Ying Peng, Hong Luo, Gui-**an Huang, **an-** Wu in Scientific Reports (2020)

  20. Article

    Open Access

    Author Correction: The Apostasia genome and the evolution of orchids

    An amendment to this paper has been published and can be accessed via a link at the top of the paper.

    Guo-Qiang Zhang, Ke-Wei Liu, Zhen Li, Rolf Lohaus, Yu-Yun Hsiao, Shan-Ce Niu in Nature (2020)

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