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Open AccessRegulation of pro-inflammatory responses by lipoxygenases via intracellular reactive oxygen species in vitro and in vivo
Reactive oxygen species (ROS) performs a pivotal function as a signaling mediator in receptor-mediated signaling. However, the sources of ROS in this signaling have yet to be determined, but may include lipoxy...
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Open AccessCephalosporin-induced recurrent aplastic anemia
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Open AccessSmoking, longer disease duration and absence of rhinosinusitis are related to fixed airway obstruction in Koreans with severe asthma: findings from the COREA study
The clinical manifestations of severe asthma are heterogeneous. Some individuals with severe asthma develop irreversible fixed airway obstruction, which is associated with poor outcomes. We therefore investiga...
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Open AccessClinical characteristics that distinguish eosinophilic organ infiltration from metastatic nodule development in cancer patients with eosinophilia
When new space-occupying lesions are observed together with peripheral blood eosinophilia in patients diagnosed with cancer, the possibility of eosinophilic organ involvement should be differentiated from meta...
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Open AccessAllergic diseases of the skin and drug allergies – 2030. Validation of cephalosporin skin test for prediciting immediate hypersensitivity: interim analysis
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Open AccessXXIV World Allergy Congress 2015
A1 Pirfenidone inhibits TGF-b1-induced extracellular matrix production in nasal polyp-derived fibroblasts
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Open AccessS-adenosylmethionine reduces airway inflammation and fibrosis in a murine model of chronic severe asthma via suppression of oxidative stress
Increased oxidative stress has an important role in asthmatic airway inflammation and remodeling. A potent methyl donor, S-adenosylmethionine (SAMe), is known to protect against tissue injury and fibrosis thro...
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Open AccesshMSCs suppress neutrophil-dominant airway inflammation in a murine model of asthma
Although chronic eosinophilic inflammation is a common feature in patients with asthma, some patients have neutrophil-dominant inflammation, which is known to be associated with severe asthma.Human mesenchymal...
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Open AccessIL-32γ attenuates airway fibrosis by modulating the integrin-FAK signaling pathway in fibroblasts
Fibrosis in severe asthma often leads to irreversible organ dysfunction. However, the mechanism that regulates fibrosis remains poorly understood. Interleukin (IL)-32 plays a role in several chronic inflammato...
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Open AccessInternational severe asthma registry (ISAR): protocol for a global registry
Severe asthma exerts a disproportionately heavy burden on patients and health care. Due to the heterogeneity of the severe asthma population, many patients need to be evaluated to understand the clinical featu...
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Article
Open AccessMetagenome analysis using serum extracellular vesicles identified distinct microbiota in asthmatics
Different patterns of bacterial communities have been reported in the airways and gastrointestinal tract of asthmatics when compared to healthy controls. However, the blood microbiome of asthmatics is yet to b...
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Open AccessA genome-wide association study implicates the pleiotropic effect of NMUR2 on asthma and COPD
Asthma and chronic obstructive pulmonary disease (COPD) are two distinct diseases that are associated with chronic inflammation. They share common features in terms of their advanced stages and genetic factors...
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Article
Open AccessActivating transcription factor-2 supports the antioxidant capacity and ability of human mesenchymal stem cells to prevent asthmatic airway inflammation
Glutathione (GSH), an abundant nonprotein thiol antioxidant, participates in several biological processes and determines the functionality of stem cells. A detailed understanding of the molecular network media...
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Open AccessPIBF1 regulates trophoblast syncytialization and promotes cardiovascular development
Proper placental development in early pregnancy ensures a positive outcome later on. The developmental relationship between the placenta and embryonic organs, such as the heart, is crucial for a normal pregnan...
