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Article
Open AccessNon-canonical deubiquitination of OTUB1 induces IFNγ-mediated cell cycle arrest via regulation of p27 stability
The deubiquitinase OTUB1, implicated as a potential oncogene in various tumors, lacks clarity in its regulatory mechanism in tumor progression. Our study investigated the effects and underlying mechanisms of O...
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Article
Open AccessPIBF1 regulates trophoblast syncytialization and promotes cardiovascular development
Proper placental development in early pregnancy ensures a positive outcome later on. The developmental relationship between the placenta and embryonic organs, such as the heart, is crucial for a normal pregnan...
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Article
Open AccessCathepsin D promotes polarization of tumor-associated macrophages and metastasis through TGFBI-CCL20 signaling
M2-like tumor-associated macrophages (TAMs) are risk factors for cancer progression and metastasis. However, the mechanisms underlying their polarization are still not fully understood. Although cathepsin D (C...
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Article
Evaluation of the therapeutic efficacy of human skin equivalents manufactured through droplet-based bioprinting/nebulization technology
In the field of dermatology, many studies have been conducted on artificial skin to develop alternative animal testing methods for therapeutic agents for skin sensitization or skin regeneration. Recent advance...
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Article
Association between urinary arsenic concentration and genetic polymorphisms in Korean adults
Arsenic (As) is a human carcinogen widely distributed in the environment. This study evaluated the association between the urinary As concentration and single nucleotide polymorphisms (SNPs) in Korean adults t...
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Article
Open AccessTGFBI remodels adipose metabolism by regulating the Notch-1 signaling pathway
Extracellular matrix proteins are associated with metabolically healthy adipose tissue and regulate inflammation, fibrosis, angiogenesis, and subsequent metabolic deterioration. In this study, we demonstrated ...
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Article
Non-genomic activation of the AKT-mTOR pathway by the mitochondrial stress response in thyroid cancer
Cancer progression is associated with metabolic reprogramming and causes significant intracellular stress; however, the mechanisms that link cellular stress and growth signalling are not fully understood. Here...
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Article
Exposure Levels and Contributing Factors of Various Arsenic Species and Their Health Effects on Korean Adults
Arsenic is a human carcinogen. Data on urinary arsenic species analyses of Koreans are limited. This study evaluated the arsenic exposure level, contributing factors, and health effects in Korean adults. Dieta...
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Article
Open AccessProtective effects of Quercus acuta Thunb. fruit extract against UVB-induced photoaging through ERK/AP-1 signaling modulation in human keratinocytes
Quercus acuta Thunb. (Fagaceae) or Japanese evergreen oak is cultivated as an ornamental plant in South Korea, China, Japan, and Taiwan and used in traditional medicine. The acorn or fruit of Quercus acuta Thunb....
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Article
Open AccessEndothelial angiogenic activity and adipose angiogenesis is controlled by extracellular matrix protein TGFBI
Several studies have suggested that extracellular matrix (ECM) remodeling and the microenvironment are tightly associated with adipogenesis and adipose angiogenesis. In the present study, we demonstrated that ...
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Article
Open AccessIn vivo tracking of 14C thymidine labeled mesenchymal stem cells using ultra-sensitive accelerator mass spectrometry
Despite the tremendous advancements made in cell tracking, in vivo imaging and volumetric analysis, it remains difficult to accurately quantify the number of infused cells following stem cell therapy, especial...
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Article
Numerical study on the effect of the tip clearance of a 100 HP axial fan on the aerodynamic performance and unsteady stall characteristics
In this study, a numerical analysis was conducted to investigate the effect of the tip clearance on the aerodynamic performance, internal flow characteristics, and stall region characteristics of an axial fan....
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Article
Synergistically Enhanced Electrocatalytic Stability of Pt Catalyst Supported by Doped Porous Carbon Nanostructure for Oxygen Reduction Reaction
In proton exchange membrane fuel cells, the utilization of supporting materials for Pt-based catalysts is an effective approach to improve the oxygen reduction reaction (ORR) performance. In this study, a dope...
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Article
Open AccessVitrification for cryopreservation of 2D and 3D stem cells culture using high concentration of cryoprotective agents
Vitrification is the most promising technology for successful cryopreservation of living organisms without ice crystal formation. However, high concentrations (up to ~ 6–8 M) of cryoprotective agents (CPAs) us...
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Article
Post-Marketing Pooled Safety Analysis for CT-P13 Treatment of Patients with Immune-Mediated Inflammatory Diseases in Observational Cohort Studies
At EU marketing authorisation, safety data for CT-P13 (biosimilar infliximab) were limited, particularly in some indications, and uncommon adverse events (AEs) could not be evaluated among relatively small ana...
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Article
Open AccessClinical Value of Lymph Node Ratio Integration with the 8th Edition of the UICC TNM Classification and 2015 ATA Risk Stratification Systems for Recurrence Prediction in Papillary Thyroid Cancer
Recently, the 2015 American Thyroid Association (ATA) risk stratification and the 8th edition of the American Joint Committee on Cancer/Union for International Cancer Control (AJCC/UICC) TNM staging system were r...
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Article
Open AccessInhibition of MMP-2 and MMP-9 activities by solvent-partitioned Sargassum horneri extracts
Matrix metalloproteinases (MMPs) are linked with several complications such as metastasis of cancer progression, oxidative stress, and hepatic fibrosis. Brown seaweeds are being extensively studied for their b...
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Article
Solvent-partitioned fractions from Ishige okamurae extract inhibit MMP-2 and MMP-9 activities in human fibrosarcoma cells in vitro
Matrix metalloproteinases (MMPs) are endopeptidases that take significant roles in extracellular matrix degradation and therefore linked with several complications such as metastasis of cancer progression, oxi...
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Article
Yonsei Experience of 5000 Gasless Transaxillary Robotic Thyroidectomies
Since the use of robot systems in thyroid surgery was introduced in 2007, we have advanced a novel method of robotic thyroidectomy (RT) using a gasless transaxillary approach (TAA). We report our experience wi...
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Article
Transaxillary robotic modified radical neck dissection: a 5-year assessment of operative and oncologic outcomes
Robotic modified radical neck dissection (MRND) using a gasless transaxillary approach has been reported to be a safe and meticulous technique in patients with papillary thyroid carcinoma (PTC) and lateral nec...
