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  1. Article

    Open Access

    Alcohol consumption and breast cancer prognosis after breast cancer diagnosis: a systematic review and meta‑analysis of the Japanese Breast Cancer Society Clinical Practice Guideline, 2022 edition

    Alcohol consumption is internationally recognized as one of the compelling risk factors for breast cancer, but it does not necessarily correlate with the prognosis of breast cancer patients. Alcohol consumptio...

    Tsunehisa Nomura, Masaaki Kawai, Yuna Fukuma, Yoshikazu Koike… in Breast Cancer (2023)

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  2. Article

    Open Access

    Resistance to cyclin-dependent kinase (CDK) 4/6 inhibitors confers cross-resistance to other CDK inhibitors but not to chemotherapeutic agents in breast cancer cells

    Combined endocrine therapy with a cyclin-dependent kinase (CDK) 4/6 inhibitor has been indicated to improve not only progression-free survival, but also overall survival in patients with hormone receptor (HR)-...

    Ryohei Ogata, Emi Kishino, Wataru Saitoh, Yoshikazu Koike… in Breast Cancer (2021)

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  3. No Access

    Article

    Anti-cell growth and anti-cancer stem cell activity of the CDK4/6 inhibitor palbociclib in breast cancer cells

    A cyclin-dependent kinase (CDK) 4/6 inhibitor, palbociclib, has been used to treat patients with estrogen receptor (ER)-positive (+) and human epidermal growth factor receptor (HER) 2-negative (−) advanced bre...

    Emi Kishino, Ryohei Ogata, Wataru Saitoh, Yoshikazu Koike, Yusuke Ohta… in Breast Cancer (2020)

  4. Article

    Open Access

    CD1d- and PJA2-related immune microenvironment differs between invasive breast carcinomas with and without a micropapillary feature

    Invasive micropapillary carcinoma (IMPC) of the breast is characterized by its unique morphology and frequent nodal metastasis. However, the mechanism for development of this unique subtype has not been clearl...

    Naoki Kanomata, Junichi Kurebayashi, Yoshikazu Koike, Rin Yamaguchi… in BMC Cancer (2019)

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  5. No Access

    Article

    Comprehensive immunohistochemical analyses on expression levels of hedgehog signaling molecules in breast cancers

    The hedgehog (Hh) signaling pathway plays important roles in cell proliferation, malignant progression, invasion and metastasis, and the expansion of cancer stem cells (CSCs). Comprehensive immunohistochemical...

    Junichi Kurebayashi, Naoki Kanomata, Yoshikazu Koike, Yusuke Ohta… in Breast Cancer (2018)

  6. No Access

    Article

    Anti-cell growth and anti-cancer stem cell activities of the non-canonical hedgehog inhibitor GANT61 in triple-negative breast cancer cells

    Triple-negative breast cancer (TNBC) exhibits biologically aggressive behavior and has a poor prognosis. Novel molecular targeting agents are needed to control TNBC. Recent studies revealed that the non-canoni...

    Yoshikazu Koike, Yusuke Ohta, Wataru Saitoh, Tetsumasa Yamashita… in Breast Cancer (2017)