20 Result(s)

Article

Analysis of Maternal and Fetal Oxidative Stress During Delivery with Epidural Analgesia

Childbirth is a stressful event for mothers, and labor epidural analgesia (LEA) may reduce mental stress. Mental stressors include labor pain, fear, and anxiety, which induce oxidative stress. In this study, w...

Tomoo Yuba, Yoshihisa Koyama, Yuki Kinishi, Reiko Uokawa… in Reproductive Sciences (2024)

Article

Si-based agent alleviated small bowel ischemia–reperfusion injury through antioxidant effects

The progression of small bowel ischemia–reperfusion (IR) injury causes cells in the intestinal tract to undergo necrosis, necessitating surgical resection, which may result in loss of intestinal function. Ther...

Masato Shimada, Yoshihisa Koyama, Yuki Kobayashi, Yasunari Matsumoto… in Scientific Reports (2024)

Article

Effect of the new silicon-based agent on the symptoms of interstitial pneumonitis

Interstitial pneumonia (IP) is a collective term for diseases whose main lesion is fibrosis of the pulmonary interstitium, and the prognosis associated with acute exacerbation of these conditions is often poor...

Masato Shimada, Yoshihisa Koyama, Yuki Kobayashi, Hikaru Kobayashi… in Scientific Reports (2023)

Article

Author Correction: A new therapy against ulcerative colitis via the intestine and brain using the Si-based agent

Yoshihisa Koyama, Yuki Kobayashi, Ikuei Hirota, Yuanjie Sun… in Scientific Reports (2022)

Article

A new therapy against ulcerative colitis via the intestine and brain using the Si-based agent

Ulcerative colitis (UC) is a non-specific inflammatory bowel disease that causes ulcers and erosions in the colonic mucosa and becomes chronic with cycles of amelioration and exacerbation. Because its exact et...

Yoshihisa Koyama, Yuki Kobayashi, Ikuei Hirota, Yuanjie Sun… in Scientific Reports (2022)

Article

Hydrogen-generating Si-based agent protects against skin flap ischemia–reperfusion injury in rats

Hydrogen is effective against ischemia–reperfusion (I/R) injury in skin flaps. However, the difficulty of continuously administering a sufficient amount of hydrogen using conventional methods has been an issue...

Naoya Otani, Koichi Tomita, Yuki Kobayashi, Kazuya Kuroda… in Scientific Reports (2022)

Article

Diagnosis and treatment of gastric hamartomatous inverted polyp (GHIP) using a modified combination of laparoscopic and endoscopic approaches to neoplasia with a non-exposure technique (modified CLEAN-NET): a case report

Gastric hamartomatous inverted polyp (GHIP) is a pathological condition where enlarged gastric glands with cystic dilatation grow in the submucosa. It is difficult to excise the tissue due to its location. In ...

Suguru Hayase, Mei Sakuma, Shun Chida, Masaru Saito, Hirofumi Ami… in Surgical Case Reports (2020)

Article

Renoprotective and neuroprotective effects of enteric hydrogen generation from Si-based agent

We have developed Si-based agent which can generate a large amount of hydrogen. Si-based agent continues generating hydrogen for more than 24 h by the reaction with water under conditions similar to those in b...

Yuki Kobayashi, Ryoichi Imamura, Yoshihisa Koyama, Makoto Kondo… in Scientific Reports (2020)

Article

Molecular mechanisms of Wischnewski spot development on gastric mucosa in fatal hypothermia: an experimental study in rats

Numerous dark-brown-coloured small spots called “Wischnewski spots” are often observed in the gastric mucosa in the patients dying of hypothermia, but the molecular mechanisms through which they develop remain...

Chihpin Yang, Kana Sugimoto, Yukie Murata, Yuichiro Hirata… in Scientific Reports (2020)

Article

Fibroblast growth factor 12 is expressed in spiral and vestibular ganglia and necessary for auditory and equilibrium function

We investigated fibroblast growth factor 12 (FGF12) as a transcript enriched in the inner ear by searching published cDNA library databases. FGF12 is a fibroblast growth factor homologous factor, a subset of t...

Yukiko Hanada, Yukiko Nakamura, Yoshiyuki Ozono, Yusuke Ishida… in Scientific Reports (2018)

Article

Inhibition of RGMa alleviates symptoms in a rat model of neuromyelitis optica

Neuromyelitis optica (NMO) is an autoimmune disease associated with NMO immunoglobulin G (NMO-IgG), an antibody that selectively binds to the aquaporin-4. Here, we established a localized NMO model by injectin...

Kana Harada, Yuki Fujita, Tatsusada Okuno, Shogo Tanabe… in Scientific Reports (2018)

Article

Building a 5-HT3A Receptor Expression Map in the Mouse Brain

Of the many serotonin receptors, the type 3 receptors (5-HT3R) are the only ionotropic ones, playing a key role in fast synaptic transmission and cognitive and emotional brain function through controlled neuro...

Yoshihisa Koyama, Makoto Kondo, Shoichi Shimada in Scientific Reports (2017)

Article

Concomitant existence of pheochromocytoma in a patient with multiple endocrine neoplasia type 1

Multiple endocrine neoplasia type 1 (MEN1) is an autosomal-dominant inherited disorder that is classically characterized by the presence of neoplastic lesions of the parathyroid glands, the anterior pituitary ...

Ryo Okada, Tatsuo Shimura, Shigeyuki Tsukida, ** Ando… in Surgical Case Reports (2016)

Article

Association between chronic stress-induced structural abnormalities in Ranvier nodes and reduced oligodendrocyte activity in major depression

Repeated stressful events are associated with the onset of major depressive disorder (MDD). We previously showed oligodendrocyte (OL)-specific activation of the serum/glucocorticoid-regulated kinase (SGK)1 cas...

Shingo Miyata, Manabu Taniguchi, Yoshihisa Koyama, Shoko Shimizu… in Scientific Reports (2016)

Article

Ultrastructural Localization of Adiponectin protein in Vasculature of Normal and Atherosclerotic mice

Adiponectin, adipose-specific secretory protein, abundantly circulates in bloodstream and its concentration is around 1000-fold higher than that of other cytokines and hormones. Hypoadiponectinemia is a risk f...

Takuya Mori, Yoshihisa Koyama, Norikazu Maeda, Yukiko Nakamura… in Scientific Reports (2014)