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Open AccessInvestigation of the effects of urea cycle amino acids on the expression of ALB and CEBPB in the human hepatocellular carcinoma cell line FLC-4
Cell lines are powerful tools for research into liver function at the molecular level. However, they are generally unsuitable for rigorously assessing the effects of amino acid composition, because many lines ...
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Article
Open AccessBio-artificial bone formation model with a radial-flow bioreactor for implant therapy—comparison between two cell culture carriers: porous hydroxyapatite and β-tricalcium phosphate beads
Bone grafting is necessary before dental implant treatment in patients with jaw bone defects. Currently, autologous bone grafting is a major burden on the patient. However, it is impossible to form a sufficien...
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Article
Biochemical and histochemical analyses of lecithin:retinol acyltransferase from polar bear (Ursus maritimus) livers
Vitamin A is a fat-soluble vitamin required for many physiological functions. It is known that polar bears (Ursus maritimus) store a large amount of vitamin A within hepatic stellate cells (HSCs). However, the mo...
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Article
The stellate cell system (vitamin A-storing cell system)
Past, present, and future research into hepatic stellate cells (HSCs, also called vitamin A-storing cells, lipocytes, interstitial cells, fat-storing cells, or Ito cells) are summarized and discussed in this r...
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Article
Retraction Note: A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPAR-γ transactivation
Although the authors believe that the key finding and conclusions are still valid, recently detected image manipulation in the published figures undermines their full confidence in the integrity of the study. ...
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Article
Erratum: A histone lysine methyltransferase activated by non-canonical Wnt signalling supresses PPAR-γ transactivation
Nat. Cell Biol. 9, 1273–1285 (2007); published online 21st October 2007 In the version of this Article initially published, Figs 6a and 6c contained panels that were inadvertently duplicated. In Fig. 6a, the p...
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Article
A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPAR-γ transactivation
Histone modifications induced by activated signalling cascades are crucial to cell-lineage decisions. Osteoblast and adipocyte differentiation from common mesenchymal stem cells is under transcriptional contro...